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   Articles with "cepharanthine" as a keyword



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Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC)

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recommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2020.1737013

Abstract: ABSTRACT Objectives: Cepharanthine exhibits a wide range of therapeutic effects against numerous cancers by virtue of its pleiotropic mechanisms. However, cepharanthine monotherapy has insufficient drug efficacy for cancers in animal models and clinical trials. The… read more here.

Keywords: hepatocellular carcinoma; cepharanthine hydrochloride; hcc; carcinoma hcc ... See more keywords
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Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus

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recommendations! Published in 2021 at "Briefings in bioinformatics"

DOI: 10.1093/bib/bbaa387

Abstract: Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are urgently required. We studied an already-approved botanical drug cepharanthine (CEP) in a cell culture model of GX_P2V, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related… read more here.

Keywords: cepharanthine; heat shock; related coronavirus; cov related ... See more keywords
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Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia‐inducible factor activation

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recommendations! Published in 2020 at "Clinical and Experimental Dermatology"

DOI: 10.1111/ced.14533

Abstract: Cepharanthine (CEP), a compound extracted from the vine Stephania cephalantha, is commonly prescribed to treat alopecia areata; however, the scientific evidence for its efficacy is limited. read more here.

Keywords: human dermal; cepharanthine induces; induces proliferation; cepharanthine ... See more keywords
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Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation.

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recommendations! Published in 2019 at "Die Pharmazie"

DOI: 10.1691/ph.2019.9562

Abstract: Activation of microglial cells in the brain has been considered to be associated with various neurodegenerative diseases (NDD). In this study, cepharanthine, a bisbenzylisoquinoline alkaloid, was found to inhibit lipopolysaccharide (LPS)-induced microglial activation. Cepharanthine suppressed… read more here.

Keywords: bisbenzylisoquinoline alkaloid; induced microglial; cepharanthine; cepharanthine bisbenzylisoquinoline ... See more keywords
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Pharmacological Effects and Clinical Prospects of Cepharanthine

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27248933

Abstract: Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence… read more here.

Keywords: prospects cepharanthine; effects clinical; cepharanthine; pharmacological effects ... See more keywords