Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12552
Abstract: Acid ceramidase catalyzes the degradation of ceramide into sphingosine and a free fatty acid. Acid ceramidase deficiency results in lipid accumulation in many tissues and leads to the development of Farber disease (FD). Typical manifestations… read more here.
Keywords: skin; ceramidase deficiency; acid ceramidase; mouse ... See more keywords
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01723
Abstract: Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors.… read more here.
Keywords: inhibition; carmofur; molecular mechanism; ceramidase ... See more keywords
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2150183
Abstract: Abstract Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC… read more here.
Keywords: discovery novel; acid ceramidase; high throughput; ceramidase ... See more keywords
Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri
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DOI: 10.1371/journal.pone.0194863
Abstract: Amorphophallus is a perennial herbaceous plant species mainly distributed in the tropics or subtropics of Asia and Africa. It has been used as a traditional medicine for a long time and now is utilized for… read more here.
Keywords: metabolic pathway; neutral ceramidase; ceramidase; gene ... See more keywords
Molecular mechanism of inhibition of acid ceramidase by carmofur.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.2210/pdb6mhm/pdb
Abstract: Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors.… read more here.
Keywords: acid ceramidase; carmofur; ceramidase; inhibition ... See more keywords