Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27818
Abstract: Sphingosine kinases (SphKs) and ceramide kinase (CerK) phosphorylate sphingosine to sphingosine‐1‐phosphate (S1P) and ceramide to ceramide‐1‐phosphate (C1P), respectively. S1P and C1P are bioactive lipids that regulate cell fate/function and human health/diseases. The translocation and activity… read more here.
Keywords: sphk1; ceramide; c1p; translocation ... See more keywords
C6 ceramide motivates the anticancer sensibility induced by PKC412 in preclinical head and neck squamous cell carcinoma models
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26831
Abstract: The purpose of this study was to evaluate the anti–head and neck squamous cell carcinoma (anti‐HNSCC) cell activity by C6 ceramide and multikinase inhibitor PKC412. Experiments were performed on HNSCC cell lines (SQ20B and SCC‐9)… read more here.
Keywords: carcinoma; ceramide; hnscc; pkc412 ... See more keywords
Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12233
Abstract: Abstract The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we report that the ceramide transport protein (CERT) mediates a non‐vesicular transport… read more here.
Keywords: cert; function; extracellular vesicles; sphingolipid composition ... See more keywords
Ceramide Analysis by Multiple Linked-Scan Mass Spectrometry Using a Tandem Quadrupole Instrument.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1410-5_9
Abstract: Ceramides are a special class of sphingolipids and play a central role in sphingolipid metabolism, and have diverse structures. In this book chapter, tandem quadrupole mass spectrometric approaches applying multiple linked scannings including various constant… read more here.
Keywords: instrument; tandem quadrupole; mass; ceramide ... See more keywords
Geniposide ameliorates chronic unpredictable mild stress induced depression-like behavior through inhibition of ceramide-PP2A signaling via the PI3K/Akt/GSK3β axis.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05895-8
Abstract: BACKGROUND Depression is a severe mental disorder. Unfortunately, more than half of patients with major depression disorder cannot achieve remission after initial treatment with an antidepressant. Geniposide, a bioactive iridoid glycoside isolated from Gardenia jasminoides… read more here.
Keywords: depression; geniposide; pi3k akt; ceramide ... See more keywords
Natural Ceramides and Lysophospholipids Cosegregate in Fluid Phosphatidylcholine Bilayers.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.02.002
Abstract: The mode of interactions between palmitoyl lysophosphatidylcholine (palmitoyl lyso-PC) or other lysophospholipids (lyso-PLs) and palmitoyl ceramide (PCer) or other ceramide analogs in dioleoylphosphatidylcholine (DOPC) bilayers has been examined. PCer is known to segregate laterally into… read more here.
Keywords: pcer; lyso pls; ceramide; palmitoyl ... See more keywords
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.02.034
Abstract: Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear. Here, we investigated the association of ceramide metabolism and ceramide-interacting proteins… read more here.
Keywords: ceramide associated; ceramide; ceramide protein; lipotoxic cardiomyopathy ... See more keywords
Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress
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DOI: 10.1016/j.celrep.2018.09.038
Abstract: Summary Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The anorectic… read more here.
Keywords: energy; hypothalamic ceramide; effect; ceramide ... See more keywords
The enzymatic sphingomyelin to ceramide conversion increases the shear membrane viscosity at the air-water interface.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in colloid and interface science"
DOI: 10.1016/j.cis.2017.07.014
Abstract: Whereas most of lipids have viscous properties and they do not have significant elastic features, ceramides behave as very rigid solid assemblies, displaying viscoelastic behaviour at physiological temperatures. The present review addresses the surface rheology… read more here.
Keywords: viscosity; interface; enzymatic sphingomyelin; ceramide ... See more keywords
Evidence for ceramide induced cytotoxicity in retinal ganglion cells.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108762
Abstract: Ceramides are bioactive compounds that play important roles in regulating cellular responses to extracellular stimuli and stress. Previous studies have shown that ceramides contribute to retinal degeneration associated with ischemic and ocular hypertensive stress. Acid… read more here.
Keywords: ocular hypertensive; retinal ganglion; ganglion cells; evidence ... See more keywords
Limonoids and unsaturated fatty acids present in Melia toosendan increase ceramide production in keratinocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Fitoterapia"
DOI: 10.1016/j.fitote.2021.105058
Abstract: The skin barrier prevents moisture evaporation and the entry of foreign substances such as allergens. Ceramides are one of the most important factors for maintaining skin barrier function. Melia toosendan is a plant of the… read more here.
Keywords: ceramide production; fatty acids; ceramide; melia toosendan ... See more keywords