Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis
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DOI: 10.1038/s41598-018-20102-z
Abstract: Colitis, an inflammatory disease of the digestive tract, is increasing in incidence and prevalence. Intestinal inflammation can occur as a consequence of dysfunctions in sphingolipid metabolism. In this study we used ceramide synthase 6 (CerS6)… read more here.
Keywords: colitis; model; cers6 deficient; ceramide synthase ... See more keywords
Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
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DOI: 10.1042/bsr20181743
Abstract: Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of… read more here.
Keywords: homo sapiens; pathological significance; synthase cers; ceramide synthase ... See more keywords
Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation.
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DOI: 10.1242/jcs.260923
Abstract: Maintaining the integrity of the nuclear envelope (NE) is essential for preventing genomic DNA damage. Recent studies have shown that enzymes that catalyze lipid synthesis are involved in NE maintenance, but the underlying mechanism remains… read more here.
Keywords: nuclear envelope; golgi; tlc4; integrity ... See more keywords