Convergent evolution of bacterial ceramide synthesis
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DOI: 10.1038/s41589-021-00948-7
Abstract: The bacterial domain produces numerous types of sphingolipids with various physiological functions. In the human microbiome, commensal and pathogenic bacteria use these lipids to modulate the host inflammatory system. Despite their growing importance, their biosynthetic… read more here.
Keywords: convergent evolution; ceramide; bacterial ceramide; pathway ... See more keywords
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adx2681
Abstract: Increasing evidence implicates ceramides in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH). However, the therapeutic potential of liver-targeted ceramide lowering remains unclear. In this study, we demonstrate that elevated ceramide levels in MASH patients and… read more here.
Keywords: targeted inhibition; ceramide synthesis; ceramide; novo ceramide ... See more keywords
Increased de novo ceramide synthesis and accumulation in failing myocardium.
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DOI: 10.1172/jci.insight.96203
Abstract: Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardial tissue and serum from patients with severe heart failure… read more here.
Keywords: novo ceramide; accumulation; ceramide synthesis; failing myocardium ... See more keywords