The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00554-y
Abstract: Joubert syndrome is characterized by unique malformation of the cerebellar vermis. More than thirty Joubert syndrome genes have been identified, including ARL13B. However, its role in cerebellar development remains unexplored. We found that knockdown or… read more here.
Keywords: early cerebellar; joubert syndrome; cerebellar development; cerebellar ... See more keywords
Immunoreactivity pattern of calretinin in the developing human cerebellar cortex.
Sign Up to like & getrecommendations! Published in 2017 at "Acta histochemica"
DOI: 10.1016/j.acthis.2017.01.005
Abstract: The immunohistochemical expression of the calcium-binding protein calretinin during human cerebellar development has been investigated in this study. Human cerebellum samples, obtained from 7 fetuses and newborns ranging from 11 to 38 weeks of gestation,… read more here.
Keywords: cerebellar interneurons; human cerebellar; calretinin; immunoreactivity ... See more keywords
Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109721
Abstract: SUMMARY Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipeline.… read more here.
Keywords: homologous organization; sensory motor; cerebellar pathways; organization cerebellar ... See more keywords
Reader Response: Progression of Nigrostriatal Denervation in Cerebellar Multiple System Atrophy: A Prospective Study
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200810
Abstract: We read with great interest the study by Wirth et al.1 The authors evaluate nigrostriatal dopaminergic denervation (NSDD) progression in 85 patients with sporadic late-onset cerebellar ataxia (SLOCA) using the [1231]-FP-CIT-SPECT, associated with SARA, UPDRS-III,… read more here.
Keywords: multiple system; system atrophy; denervation; cerebellar multiple ... See more keywords
Author Response: Progression of Nigrostriatal Denervation in Cerebellar Multiple System Atrophy: A Prospective Study
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200811
Abstract: We thank Teive et al. for their valuable comments on our work.1 We agree that REM sleep behavior disorders (RBD) are a typical hallmark of α-synucleinopathies, including multiple system atrophy (MSA).2 Some pieces of evidence… read more here.
Keywords: msa; cerebellar; multiple system; system atrophy ... See more keywords
The Clinical Concept of LTDpathy: Is Dysregulated LTD Responsible for Prodromal Cerebellar Symptoms?
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12030303
Abstract: Long-term depression at parallel fibers-Purkinje cells (PF-PC LTD) is essential for cerebellar motor learning and motor control. Recent progress in ataxiology has identified dysregulation of PF-PC LTD in the pathophysiology of certain types of immune-mediated… read more here.
Keywords: cas; concept ltdpathy; cerebellar; clinical concept ... See more keywords
Metabolic Heterogeneity of Cerebral Cortical and Cerebellar Astrocytes
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13010184
Abstract: Astrocytes play critical roles in regulating neuronal synaptogenesis, maintaining blood–brain barrier integrity, and recycling neurotransmitters. Increasing numbers of studies have suggested astrocyte heterogeneity in morphology, gene profile, and function. However, metabolic phenotype of astrocytes in… read more here.
Keywords: cerebellar astrocytes; cortical astrocytes; metabolic heterogeneity; cortical cerebellar ... See more keywords