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Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00554-y
Abstract: Joubert syndrome is characterized by unique malformation of the cerebellar vermis. More than thirty Joubert syndrome genes have been identified, including ARL13B. However, its role in cerebellar development remains unexplored. We found that knockdown or…
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Keywords:
early cerebellar;
joubert syndrome;
cerebellar development;
cerebellar ... See more keywords
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Published in 2019 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-019-0152-2
Abstract: The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders…
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Keywords:
brain disorders;
motor;
cerebellar development;
behaviour ... See more keywords
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Published in 2021 at "Nature neuroscience"
DOI: 10.1038/s41593-021-00872-y
Abstract: The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint required to integrate environmental cues with developing motor, cognitive and emotional skills into adulthood. Although mature cerebellar neuroanatomy is well studied,…
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Keywords:
human cerebellar;
cell types;
cerebellar development;
cell ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42523
Abstract: The role of Wnt5a has been extensively explored in various aspects of development but its role in cerebellar development remains elusive. Here, for the first time we unravel the expression pattern and functional significance of…
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Keywords:
regulator neurogenesis;
cerebellar development;
development;
wnt5a crucial ... See more keywords
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Published in 2023 at "Neuropathology and applied neurobiology"
DOI: 10.1111/nan.12903
Abstract: The childhood brain tumour medulloblastoma is typically classified into multiple discrete molecular subgroups with characteristic DNA methylation and expression patterns. Several of these subgroups are used as, or proposed to be, an effective basis for…
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Keywords:
medulloblastoma;
cerebellar development;
connection;
fetal cerebellar ... See more keywords
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Published in 2019 at "Science"
DOI: 10.1126/science.aax7526
Abstract: Close-up of human cerebellar development Early on, cerebellar development shares similarities across humans, nonhuman primates, and even mice. But differences emerge while development progresses, as cellular and molecular analyses by Haldipur et al. now reveal.…
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Keywords:
developing human;
cerebellar development;
human cerebellum;
progenitor ... See more keywords
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Published in 2022 at "Annual review of neuroscience"
DOI: 10.1146/annurev-neuro-111020-091953
Abstract: Developmental abnormalities of the cerebellum are among the most recognized structural brain malformations in human prenatal imaging. Yet reliable information regarding their cause in humans is sparse, and few outcome studies are available to inform…
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Keywords:
cerebellar development;
transcriptomics implications;
human cerebellar;
development transcriptomics ... See more keywords
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Published in 2021 at "Developmental Neuroscience"
DOI: 10.1159/000515189
Abstract: Autism spectrum disorders (ASD) comprise a group of heterogeneous neurodevelopmental conditions characterized by impaired social interactions and repetitive behaviors with symptom onset in early infancy. The genetic risks for ASD have long been appreciated: concordance…
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Keywords:
spectrum disorders;
cerebellar development;
abnormal cerebellar;
development ... See more keywords
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Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00231
Abstract: Motor control and learning impairments are common complications in individuals with autism spectrum disorder (ASD). Abnormal cerebellar development during critical phases may disrupt these motor functions and lead to autistic motor dysfunction. However, the underlying…
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Keywords:
cerebellar development;
abnormal cerebellar;
motor;
btbr mice ... See more keywords
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Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1068288
Abstract: Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects…
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Keywords:
cerebellar development;
development preterm;
preterm birth;
pathology ... See more keywords
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Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1214635
Abstract: The cerebellum plays a pivotal role in the control and regulation of motor functions, contributing to the coordination, precision and timing of movements; in addition, recent evidence suggests its involvement also in cognitive and emotional…
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Keywords:
cerebellar development;
editorial cerebellar;
development;
development medulloblastoma ... See more keywords