LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "cerebellar granule" as a keyword



Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons

Sign Up to like & get
recommendations! Published in 2017 at "Neurotoxicity Research"

DOI: 10.1007/s12640-017-9749-2

Abstract: Glia over-stimulation associates with amyloid deposition contributing to the progression of central nervous system neurodegenerative disorders. Here we analyze the molecular mechanisms mediating microglia-dependent neurotoxicity induced by prion protein (PrP)90–231, an amyloidogenic polypeptide corresponding to… read more here.

Keywords: cerebellar granule; prp90 231; prion protein; neurotoxicity ... See more keywords

RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival.

Sign Up to like & get
recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.06.098

Abstract: Cerebellar granule neurons (CGNs) undergo programmed cell death during the first postnatal week of mouse development, coincident with sustained expression of the death receptor p75NTR. Although ablation of p75NTR does not affect CGN cell death,… read more here.

Keywords: death; cerebellar granule; death receptor; receptor p75ntr ... See more keywords

N-acetyl-l-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons.

Sign Up to like & get
recommendations! Published in 2018 at "Toxicology"

DOI: 10.1016/j.tox.2017.10.017

Abstract: Cadmium is a highly toxic heavy metal that is capable of accumulating in the body via direct exposure or through the alimentary and respiratory tract, leading to neurodegeneration. In this article, we show that the… read more here.

Keywords: cerebellar granule; cultured cerebellar; cd2 induced; acetyl cysteine ... See more keywords

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning

Sign Up to like & get
recommendations! Published in 2017 at "Nature Neuroscience"

DOI: 10.1038/nn.4531

Abstract: Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track… read more here.

Keywords: cerebellar granule; motor learning; cells acquire; granule cells ... See more keywords

Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells

Sign Up to like & get
recommendations! Published in 2024 at "Cell Death Discovery"

DOI: 10.1038/s41420-024-02262-2

Abstract: The Jun dimerization protein (Jdp2) gene is active in mouse cerebellar granule cells and its protein product plays a crucial role in the formation of the cerebellum lobes through programmed cell death. However, the role… read more here.

Keywords: differentiation; jdp2; purkinje cells; cerebellar granule ... See more keywords

Neuroprotective Effect of a Pharmaceutical Extract of Cannabis with High Content on CBD Against Rotenone in Primary Cerebellar Granule Cell Cultures and the Relevance of Formulations.

Sign Up to like & get
recommendations! Published in 2023 at "Cannabis and cannabinoid research"

DOI: 10.1089/can.2022.0289

Abstract: Introduction: Preclinical research supports the benefits of pharmaceutical cannabis-based extracts for treating different medical conditions (e.g., epilepsy); however, their neuroprotective potential has not been widely investigated. Materials and Methods: Using primary cultures of cerebellar granule… read more here.

Keywords: cannabis; effect; cerebellar granule; epi ... See more keywords

MDB-13. GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA

Sign Up to like & get
recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.462

Abstract: Abstract BACKGROUND Germline loss-of-function (LOF) variants in Elongator complex protein 1 (ELP1) are the most prevalent predisposing genetic events observed in medulloblastoma (MB), accounting for 30% of the Sonic Hedgehog 3 subtype (SHH-3). Molecularly, ELP1-associated… read more here.

Keywords: neuron progenitors; lof; elp1; cerebellar granule ... See more keywords

Phosphacan acts as a repulsive cue in murine and rat cerebellar granule cells in a TAG‐1/GD3 rafts‐dependent manner

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.15709

Abstract: Phosphacan, a chondroitin sulfate proteoglycan, is a repulsive cue of cerebellar granule cells. This study aims to explore the molecular mechanism. The glycosylphosphatidylinositol‐anchored neural adhesion molecule TAG‐1 is a binding partner of phosphacan, suggesting that… read more here.

Keywords: cerebellar granule; bdnf induced; induced migration; granule cells ... See more keywords

Behavioral decline in Shank3Δex4–22 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes

Sign Up to like & get
recommendations! Published in 2024 at "Molecular Autism"

DOI: 10.1186/s13229-024-00628-y

Abstract: SHANK3, a gene encoding a synaptic scaffolding protein, is implicated in autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS). Despite evidence of regression or worsening of ASD-like symptoms in individuals with PMS,… read more here.

Keywords: cerebellar granule; granule cell; shank3 ex4; shank3 ... See more keywords

Electrophysiological study of the effects of side products of RuBi-GABA uncaging on GABAA receptors in cerebellar granule cells

Sign Up to like & get
recommendations! Published in 2022 at "Biomolecular Concepts"

DOI: 10.1515/bmc-2022-0022

Abstract: Abstract The study of the GABAA receptor itself and its pharmacology is of paramount importance for shedding light on the role of this receptor in the central nervous system. Caged compounds have emerged as powerful… read more here.

Keywords: gabaa receptors; cerebellar granule; effects side; rubi gaba ... See more keywords

Notch Signaling between Cerebellar Granule Cell Progenitors

Sign Up to like & get
recommendations! Published in 2021 at "eNeuro"

DOI: 10.1523/eneuro.0468-20.2021

Abstract: Visual Abstract Cerebellar granule cells (GCs) are cells which comprise over 50% of the neurons in the entire nervous system. GCs enable the cerebellum to properly regulate motor coordination, learning, and consolidation, in addition to… read more here.

Keywords: granule; notch signaling; cell; cerebellar granule ... See more keywords