Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9749-2
Abstract: Glia over-stimulation associates with amyloid deposition contributing to the progression of central nervous system neurodegenerative disorders. Here we analyze the molecular mechanisms mediating microglia-dependent neurotoxicity induced by prion protein (PrP)90–231, an amyloidogenic polypeptide corresponding to… read more here.
Keywords: cerebellar granule; prp90 231; prion protein; neurotoxicity ... See more keywords
RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.098
Abstract: Cerebellar granule neurons (CGNs) undergo programmed cell death during the first postnatal week of mouse development, coincident with sustained expression of the death receptor p75NTR. Although ablation of p75NTR does not affect CGN cell death,… read more here.
Keywords: death; cerebellar granule; death receptor; receptor p75ntr ... See more keywords
N-acetyl-l-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2017.10.017
Abstract: Cadmium is a highly toxic heavy metal that is capable of accumulating in the body via direct exposure or through the alimentary and respiratory tract, leading to neurodegeneration. In this article, we show that the… read more here.
Keywords: cerebellar granule; cultured cerebellar; cd2 induced; acetyl cysteine ... See more keywords
Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4531
Abstract: Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track… read more here.
Keywords: cerebellar granule; motor learning; cells acquire; granule cells ... See more keywords
Neuroprotective Effect of a Pharmaceutical Extract of Cannabis with High Content on CBD Against Rotenone in Primary Cerebellar Granule Cell Cultures and the Relevance of Formulations.
Sign Up to like & getrecommendations! Published in 2023 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2022.0289
Abstract: Introduction: Preclinical research supports the benefits of pharmaceutical cannabis-based extracts for treating different medical conditions (e.g., epilepsy); however, their neuroprotective potential has not been widely investigated. Materials and Methods: Using primary cultures of cerebellar granule… read more here.
Keywords: cannabis; effect; cerebellar granule; epi ... See more keywords
Phosphacan acts as a repulsive cue in murine and rat cerebellar granule cells in a TAG‐1/GD3 rafts‐dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15709
Abstract: Phosphacan, a chondroitin sulfate proteoglycan, is a repulsive cue of cerebellar granule cells. This study aims to explore the molecular mechanism. The glycosylphosphatidylinositol‐anchored neural adhesion molecule TAG‐1 is a binding partner of phosphacan, suggesting that… read more here.
Keywords: cerebellar granule; bdnf induced; induced migration; granule cells ... See more keywords
Electrophysiological study of the effects of side products of RuBi-GABA uncaging on GABAA receptors in cerebellar granule cells
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecular Concepts"
DOI: 10.1515/bmc-2022-0022
Abstract: Abstract The study of the GABAA receptor itself and its pharmacology is of paramount importance for shedding light on the role of this receptor in the central nervous system. Caged compounds have emerged as powerful… read more here.
Keywords: gabaa receptors; cerebellar granule; effects side; rubi gaba ... See more keywords
Notch Signaling between Cerebellar Granule Cell Progenitors
Sign Up to like & getrecommendations! Published in 2021 at "eNeuro"
DOI: 10.1523/eneuro.0468-20.2021
Abstract: Visual Abstract Cerebellar granule cells (GCs) are cells which comprise over 50% of the neurons in the entire nervous system. GCs enable the cerebellum to properly regulate motor coordination, learning, and consolidation, in addition to… read more here.
Keywords: granule; notch signaling; cell; cerebellar granule ... See more keywords
Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201855
Abstract: This study shows that Prpf8 mutations associated with human retinal degeneration in mice alter circRNA expression in cerebellar granule cells and induce their apoptosis. A subset of patients with retinitis pigmentosa (RP) carry mutations in… read more here.
Keywords: degeneration; cerebellar granule; retinitis pigmentosa; prpf8 ... See more keywords
A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons
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DOI: 10.3390/biology11081097
Abstract: Simple Summary Cyclodextrins are cyclic oligosaccharides used to deplete cholesterol from cellular membranes. The effects of methyl-β-cyclodextrin (MβCD) on cellular functions originate principally from reductions in cholesterol levels. In this study, using immunocytochemistry, heterologous expression… read more here.
Keywords: task task; granule neurons; cerebellar granule; task ... See more keywords
Altered Synaptic Membrane Retrieval after Strong Stimulation of Cerebellar Granule Neurons in Cyclic GMP-Dependent Protein Kinase II (cGKII) Knockout Mice
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18112281
Abstract: The nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase (cGK) signaling pathway regulates the clustering and the recruitment of proteins and vesicles to the synapse, thereby adjusting the exoendocytic cycle to the intensity of activity.… read more here.
Keywords: cerebellar granule; stimulation; dependent protein; cgkii ... See more keywords