Guanosine and GMP increase the number of granular cerebellar neurons in culture: dependence on adenosine A2A and ionotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2019 at "Purinergic Signalling"
DOI: 10.1007/s11302-019-09677-y
Abstract: The guanine-based purines (GBPs) have essential extracellular functions such as modulation of glutamatergic transmission and trophic effects on neurons and astrocytes. We previously showed that GBPs, such as guanosine-5′-monophosphate (GMP) or guanosine (GUO), promote the… read more here.
Keywords: cerebellar neurons; gmp; number; glutamate receptors ... See more keywords
Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone‐mediated autophagy in cerebellar neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12649
Abstract: Chaperone‐mediated autophagy (CMA) is a pathway involved in the autophagy lysosome protein degradation system. CMA has attracted attention as a contributing factor to neurodegenerative diseases since it participates in the degradation of disease‐causing proteins. We… read more here.
Keywords: mediated autophagy; chaperone mediated; ataxic phenotype; cma ... See more keywords
Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00321
Abstract: Ataxia-telangiectasia (A-T) is a rare genetic disorder caused by loss of function of the ataxia-telangiectasia-mutated kinase and is characterized by a predisposition to cancer, pulmonary disease, immune deficiency and progressive degeneration of the cerebellum. As… read more here.
Keywords: disrupted gene; derived cerebellar; gene regulatory; ataxia telangiectasia ... See more keywords
Potential Neurotoxic Effects of Glioblastoma-Derived Exosomes in Primary Cultures of Cerebellar Neurons via Oxidant Stress and Glutathione Depletion
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11071225
Abstract: High-grade gliomas are the most fatal brain tumors. Grade 4 gliomas are called glioblastoma multiforme (GBM), which are associated with the poorest survival and a 5-year survival rate of less than 4%. Many patients with… read more here.
Keywords: derived exosomes; neurotoxic effects; cerebellar neurons; gbm ... See more keywords
In Search of Molecular Markers for Cerebellar Neurons
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041850
Abstract: The cerebellum, the region of the brain primarily responsible for motor coordination and balance, also contributes to non-motor functions, such as cognition, speech, and language comprehension. Maldevelopment and dysfunction of the cerebellum lead to cerebellar… read more here.
Keywords: search molecular; specific markers; markers cerebellar; cerebellum ... See more keywords
VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72981
Abstract: Although cerebellar alterations have been implicated in stress symptoms, the exact contribution of the cerebellum to stress symptoms remains to be elucidated. Here, we demonstrated the crucial role of cerebellar neurons projecting to the ventral… read more here.
Keywords: like behaviors; stress; depression; cerebellar neurons ... See more keywords