Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice.
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DOI: 10.1016/j.ntt.2020.106866
Abstract: Sonic hedgehog (SHH) signaling is essential for the differentiation and migration of early stem cell populations during cerebellar development. Dysregulation of SHH-signaling can result in cerebellar overgrowth and the formation of the brain tumor medulloblastoma.… read more here.
Keywords: ptch1; shh; social behavior; cerebellar overgrowth ... See more keywords