Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene
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DOI: 10.3389/fnmol.2022.1015220
Abstract: Introduction DYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome (DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive phenotypes, and aging. Dyrk1A has also been implicated in cerebellar… read more here.
Keywords: cerebellum transgenic; proteomic profiling; dyrk1a; transgenic mice ... See more keywords