Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs
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DOI: 10.1038/s42004-025-01598-9
Abstract: PROteolysis-Targeting Chimeras (PROTACs) are an emerging class of molecules capable of inducing a forced approximation between a protein of interest (POI) and an E3 ligase enzyme (e.g., Cereblon), leading to the degradation of the POI… read more here.
Keywords: based protacs; synthesis; clinical trials; cereblon based ... See more keywords
Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention.
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DOI: 10.4155/fmc-2022-0149
Abstract: Protease-targeted chimeras (PROTACs) have been employed as a novel therapeutic approach, utilizing the ubiquitin-proteasome system for targeted protein degradation. PROTACs are heterobifunctional molecules consisting of an E3 ligase ligand and a small-molecule inhibitor for recruiting… read more here.
Keywords: cereblon based; protease targeted; chemistry; protac molecules ... See more keywords