Inflammation and Immunomodulation in Cerebral X-linked Adrenoleukodystrophy: Review of Pathology and Interventions.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of child neurology"
DOI: 10.1177/08830738251353034
Abstract: Objectives More than half of males with X-linked adrenoleukodystrophy (ALD) develop progressive, inflammatory cerebral demyelination (cerebral adrenoleukodystrophy). Treatment for cerebral adrenoleukodystrophy is limited with no standard therapies for advanced cerebral adrenoleukodystrophy. We reviewed cerebral adrenoleukodystrophy… read more here.
Keywords: immunopathology; inflammation immunomodulation; pathology; adrenoleukodystrophy ... See more keywords
Presymptomatic Lesion in Childhood Cerebral Adrenoleukodystrophy: Timing and Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201440
Abstract: Background and Objectives We sought to characterize the natural history and standard-of-care practices between the radiologic appearance of brain lesions, the appearance of lesional enhancement, and treatment with hematopoietic stem-cell transplant or gene therapy among… read more here.
Keywords: ccald; childhood; cerebral adrenoleukodystrophy; lesion ... See more keywords
Isoprostanoid Plasma Levels Are Relevant to Cerebral Adrenoleukodystrophy Disease
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020146
Abstract: Cerebral adrenoleukodystrophy (ALD) is a rare neuroinflammatory disorder characterized by progressive demyelination. Mutations within the ABCD1 gene result in very long-chain fatty acid (VLCFA) accumulation within the peroxisome, particularly in the brain. While this VLCFA… read more here.
Keywords: plasma levels; cerebral disease; cerebral adrenoleukodystrophy; disease ... See more keywords