Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy
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DOI: 10.1002/ana.26429
Abstract: Autosomal‐dominant, Dutch‐type cerebral amyloid angiopathy (D‐CAA) offers a unique opportunity to develop biomarkers for pre‐symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D‐CAA… read more here.
Keywords: matter; amyloid angiopathy; white matter; cerebral amyloid ... See more keywords
Decreased Cerebrospinal Fluid Amyloid β 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26610
Abstract: Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA. We studied the diagnostic potential… read more here.
Keywords: amyloid angiopathy; caa; cerebrospinal fluid; amyloid ... See more keywords
Clinical significance of amyloid β positivity in patients with probable cerebral amyloid angiopathy markers
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04314-7
Abstract: PurposeWe investigated the frequency and clinical significance of amyloid β (Aβ) positivity on PET in patients with cerebral amyloid angiopathy (CAA).MethodsWe recruited 65 patients who met the modified Boston criteria for probable CAA. All underwent… read more here.
Keywords: cerebral amyloid; amyloid positivity; frequency; positivity ... See more keywords
Cerebral amyloid angiopathy: subtypes, treatment and role in cognitive impairment
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DOI: 10.1007/s00415-017-8608-7
Abstract: Accumulation of β amyloid in leptomeningeal vessels and cortical arterioles is the hallmark of cerebral amyloid angiopathy, this causes vessel stiffening, and vessel wall rupture. Alzheimer’s disease amyloid plaques are composed of β-amyloid 42, whilst… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; amyloid; clearance ... See more keywords
Recurrent intracerebral hemorrhage in patients with cerebral amyloid angiopathy: a propensity-matched case–control study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10937-4
Abstract: Objective Cerebral amyloid angiopathy (CAA) can present with intracerebral hemorrhage (ICH), convexity subarachnoid hemorrhage (SAH), and rarely acute ischemic stroke (AIS). The objective of our study was to compare the readmission rates for recurrent ICH,… read more here.
Keywords: caa; study; amyloid angiopathy; cerebral amyloid ... See more keywords
Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02174-2
Abstract: Despite its clinical relevance, cerebral amyloid angiopathy (CAA) is underdiagnosed worldwide. This retrospective study aimed to assess the incidence, etiology, predictors, and outcome of intracerebral hemorrhages (ICHs) in this region, with special focus on possible… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; etiology; lobar cerebellar ... See more keywords
Perfusion-weighted MRI in cerebral amyloid angiopathy-related transient focal neurological episodes
Sign Up to like & getrecommendations! Published in 2021 at "Neurological Sciences"
DOI: 10.1007/s10072-021-05195-1
Abstract: Sporadic cerebral amyloid angiopathy (CAA) is a common age-related cerebral small vessel disease characterized by progressive ß-amyloid deposition in the walls of small cortical arteries, arterioles, and capillaries in the cerebral cortex and overlying leptomeninges.… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; related transient; perfusion ... See more keywords
Memantine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01678-7
Abstract: Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid beta (Aβ) deposits and causes cerebral hemorrhages and dementia in elderly people. Memantine is used in Alzheimer’s disease to inhibit the glutamatergic system by blocking… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; methyl aspartate; degrading enzyme ... See more keywords
Intracisternal injection of beta-amyloid seeds promotes cerebral amyloid angiopathy
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.07.038
Abstract: Beta amyloid (Aβ) is a key component of parenchymal Aβ plaques and vascular Aβ fibrils, which lead to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). Recent studies have revealed that Aβ contained in the… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; amyloid; beta amyloid ... See more keywords
Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.04.014
Abstract: Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with… read more here.
Keywords: autoregulation; amyloid angiopathy; cerebral amyloid; phase ... See more keywords
Multi-parametric magnetic resonance imaging evaluation of cerebral amyloid angiopathy related inflammation: Case series and review of literature.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical imaging"
DOI: 10.1016/j.clinimag.2021.03.003
Abstract: Cerebral amyloid angiopathy related inflammation is a rare disorder in the spectrum of cerebral amyloid angiopathy which is characterized by vascular and/or perivascular inflammation related to Aβ deposits. Clinically, the patient typically presents with acute… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; magnetic resonance; inflammation ... See more keywords