Cyclic nucleotide phosphodiesterases (PDEs) and endothelial function in ischaemic stroke. A review.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.05.011
Abstract: BACKGROUND Endothelial dysfunction is a hallmark of cerebrovascular disease, including ischemic stroke. Modulating endothelial signalling by cyclic nucleotides, cAMP and cGMP, is a potential therapeutic target in stroke. Inhibitors of the cyclic nucleotide degrading phosphodiesterase… read more here.
Keywords: cerebral endothelial; endothelial function; cyclic nucleotide; review ... See more keywords
MRI Metrics of Cerebral Endothelial Cell Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Ageing Rats Subjected to Type-2 Diabetes.
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DOI: 10.2337/db21-0754
Abstract: Ongoing neurovascular dysfunction contributes to type-2 diabetes mellitus (T2DM) induced cognitive deficits. However, it is not known whether early post onset of T2DM interventions may reduce evolving neurovascular dysfunction and thereby lead to diminution of… read more here.
Keywords: mri metrics; dysfunction; type diabetes; cerebral endothelial ... See more keywords
Cerebral endothelial cell derived small extracellular vesicles improve cognitive function in aged diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.926485
Abstract: Small extracellular vesicles (sEVs) mediate cell-cell communication by transferring their cargo biological materials into recipient cells. Diabetes mellitus (DM) induces cerebral vascular dysfunction and neurogenesis impairment, which are associated with cognitive decline and an increased… read more here.
Keywords: cell; function; cerebral endothelial; small extracellular ... See more keywords
Hyperglycemic Condition Causes Pro-Inflammatory and Permeability Alterations Associated with Monocyte Recruitment and Deregulated NFκB/PPARγ Pathways on Cerebral Endothelial Cells: Evidence for Polyphenols Uptake and Protective Effect
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22031385
Abstract: Hyperglycemia alters the function of cerebral endothelial cells from the blood-brain barrier, increasing the risk of cerebrovascular complications during diabetes. This study evaluated the protective effect of polyphenols on inflammatory and permeability markers on bEnd3… read more here.
Keywords: hyperglycemic condition; cerebral endothelial; endothelial cells; inflammatory permeability ... See more keywords