Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23777
Abstract: Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative‐nitrosative stress… read more here.
Keywords: glucose hypometabolism; cerebral hypoperfusion; hypoperfusion glucose; hypoperfusion ... See more keywords
High-Mobility Group Box 1 Neutralization Prevents Chronic Cerebral Hypoperfusion-Induced Optic Tract Injuries in the White Matter Associated with Down-regulation of Inflammatory Responses
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00702-7
Abstract: Chronic cerebral hypoperfusion (CCH)-induced white matter lesions (WMLs) are region-specific with the optic tract (OT) displaying the most severe damages and leading to visual-based behavioral impairment. Previously we have demonstrated that anti-high-mobility group box 1… read more here.
Keywords: cerebral hypoperfusion; inflammatory responses; high mobility; optic tract ... See more keywords
Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00394-4
Abstract: Nigella sativa, a plant widely used in traditional medicine, possesses anti-inflammatory, antioxidant and neuroprotective properties. In the present study, we investigated the effect of hydroalcoholic extract of N. sativa seeds (NSE) and its active constituent,… read more here.
Keywords: following cerebral; cerebral hypoperfusion; learning memory; nigella sativa ... See more keywords
Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0641-0
Abstract: Chronic cerebral hypoperfusion (CCH) evokes mild cognitive impairment (MCI) and contributes to the progression of vascular dementia and Alzheimer’s disease (AD). How CCH induces these neurodegenerative processes that may spread along the synaptic network and… read more here.
Keywords: protein; cerebral hypoperfusion; cerebral cortex; cch ... See more keywords
Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108819
Abstract: Cannabidiol (CBD), a compound obtained from Cannabis sativa, has wide range of therapeutic properties, including mitigation of diabetes and neurodegeneration. Cerebral ischemia and consequent learning disabilities are aggravated in elderly diabetic subjects. However, there are… read more here.
Keywords: cerebral hypoperfusion; cbd; cch; diabetic rats ... See more keywords
Huoluo Yinao decoction mitigates cognitive impairments after chronic cerebral hypoperfusion in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.111846
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Huoluo Yinao decoction (HLYND) has been used to ameliorate cognitive impairment induced by chronic cerebral hypoperfusion in clinical for years. However, the exact mechanisms remain unknown. AIM OF THE STUDY To investigate the… read more here.
Keywords: cerebral hypoperfusion; huoluo yinao; hlynd; chronic cerebral ... See more keywords
Acupuncture attenuates cognitive deficits through α7nAChR mediated anti-inflammatory pathway in chronic cerebral hypoperfusion rats.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118732
Abstract: AIMS Chronic cerebral hypoperfusion (CCH) elicits inflammatory response, which contributes to the pathology of cognitive impairment. Several studies demonstrate that the alpha-7 nicotinic acetylcholine receptor (α7nAChR) can be a key component to modulate the inflammatory… read more here.
Keywords: anti inflammatory; cerebral hypoperfusion; cognitive deficits; acupuncture ... See more keywords
Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer’s disease model mouse
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Research"
DOI: 10.1016/j.neures.2018.06.002
Abstract: Cerebral neuroinflammation defines a novel pathway for progressing Alzheimer's disease (AD) pathology. We investigated immunohistological changes of neuroinflammation with nucleotide-binding domain and leucine-rich repeat (NLR)-protein 3 (NLRP3), activated caspase-1 and interleukin-1 beta (IL-1β) in a… read more here.
Keywords: alzheimer disease; cerebral hypoperfusion; chronic cerebral; pathology ... See more keywords
Protective Effects of 4-Trifluoromethyl-(E)-cinnamoyl]-L-4-F-phenylalanine Acid against Chronic Cerebral Hypoperfusion Injury through Promoting Brain-Derived Neurotrophic Factor-Mediated Neurogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00417
Abstract: Vascular dementia (VaD), one of the major consequences after stroke, is the second reason for the cognitive decline in aged people. Chronic cerebral hypoperfusion (CCH) is considered as the main cause for cognitive impairment in… read more here.
Keywords: cch; chronic cerebral; brain; cinnamoyl phenylalanine ... See more keywords
Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00637-0
Abstract: White matter injury is the major pathological alteration of subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion. It is characterized by progressive demyelination, apoptosis of oligodendrocytes and microglial activation, which leads to impairment… read more here.
Keywords: matter injury; cerebral hypoperfusion; chronic cerebral; white matter ... See more keywords
Xiaoshuan enteric-coated capsule alleviates cognitive impairment by enhancing hippocampal glucose metabolism, hemodynamics and neuroplasticity of rat with chronic cerebral hypoperfusion
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25929-0
Abstract: Chronic cerebral hypoperfusion (CCH) is identified as a critical risk factor of dementia in patients with cerebrovascular disease. Xiaoshuan enteric-coated capsule (XSECC) is a compound Chinese medicine approved by Chinese State Food and Drug Administration… read more here.
Keywords: cerebral hypoperfusion; hippocampal glucose; xsecc; glucose metabolism ... See more keywords