Renal and Cerebral Hypoxia and Inflammation During Cardiopulmonary Bypass.
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DOI: 10.1002/cphy.c210019
Abstract: Cardiac surgery-associated acute kidney injury and brain injury remain common despite ongoing efforts to improve both the equipment and procedures deployed during cardiopulmonary bypass (CPB). The pathophysiology of injury of the kidney and brain during… read more here.
Keywords: hypoxia inflammation; cpb; cardiopulmonary bypass; inflammation ... See more keywords
Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling
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DOI: 10.1002/ptr.7481
Abstract: Psoralidin (PSO) is a natural phenolic coumarin extracted from the seeds of Psoralea corylifolia L. Growing preclinical evidence indicates that PSO has anti‐inflammatory, anti‐vitiligo, anti‐bacterial, and anti‐viral effects. Growth arrest‐specific gene 6 (GAS6) and its… read more here.
Keywords: axl signaling; gas6 axl; cerebral hypoxia; injury ... See more keywords
Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets
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DOI: 10.1038/s41598-017-16983-1
Abstract: We have previously shown that cerebral Hypoxia-ischemia (HI) results in activation of Src kinase in the newborn piglet brain. We investigated the regulatory mechanism by which the pre-apoptotic proteins translocate from mitochondria to the cytosol… read more here.
Keywords: hypoxia ischemia; kinase; cytochrome smac; cerebral hypoxia ... See more keywords
Hypothermia enhances heme oxygenase 1-expressing mesenchymal stem cell-induced repair of cerebral hypoxia-ischemia
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DOI: 10.5114/aoms.2019.86784
Abstract: Mesenchymal stem cells (MSC) are known to exhibit potency for the repair of cerebral hypoxia-ischemia (HI). Heme oxygenase 1 (HO-1) is capable of inducing repair and can boost stem cell-based therapeutic effects. Hypothermia is known… read more here.
Keywords: hypoxia ischemia; hypothermia; cerebral hypoxia; repair cerebral ... See more keywords
Muscone improves hypoxia/reoxygenation (H/R)-induced neuronal injury by blocking HMGB1/TLR4/NF-κB pathway via modulating microRNA-142
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DOI: 10.7717/peerj.13523
Abstract: Previous reports have indicated that natural muscone has neuroprotective effects against cerebral hypoxia injury; however, little is known in regards to its pharmacological mechanism. In this study, we tried to evaluate the neuroprotective effects and… read more here.
Keywords: cell; hypoxia reoxygenation; muscone; hypoxia injury ... See more keywords