Spleen‐Targeted Glabridin‐Loaded Nanoparticles Regulate Polarization of Monocyte/Macrophage (Mo/Mφ) for the Treatment of Cerebral Ischemia‐Reperfusion Injury
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DOI: 10.1002/adma.202204976
Abstract: During cerebral ischemia‐reperfusion (I‐R) injury, the infiltration of monocyte/macrophages (Mo/Mφ) into the ischemic penumbra causes inflammatory damage but also regulates tissue repair in the penumbra. The regulation and balance of Mo/Mφ polarization is considered as… read more here.
Keywords: cerebral ischemia; treatment; spleen targeted; polarization ... See more keywords
Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia
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DOI: 10.1002/brb3.2522
Abstract: The participation of activating transcription factor 3 (ATF3) in transient middle cerebral artery occlusion and reperfusion injury has been reported. However, the precise mechanism of ATF3 in cerebral ischemia is little known so far. Thus,… read more here.
Keywords: cerebral ischemia; protective role; activating transcription; transcription factor ... See more keywords
In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23326
Abstract: In vivo positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChRs) is a promising tool for the imaging evaluation of neurologic and neurodegenerative diseases. However, the role of α7 nAChRs after brain diseases such… read more here.
Keywords: imaging nicotinic; vivo; cerebral ischemia; neuroinflammation ... See more keywords
Eprosartan: A closer insight into its neuroprotective activity in rats with focal cerebral ischemia–reperfusion injury
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22796
Abstract: Eprosartan (EPRO), an angiotensin receptor type‐1 (AT‐1) blocker, exhibited neuroprotective activities in ischemic stroke resulting from focal cerebral ischemia in rats. The current study aimed to clarify the neuroprotective role of EPRO in middle carotid… read more here.
Keywords: cerebral ischemia; group; focal cerebral; ischemia ... See more keywords
Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis
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DOI: 10.1002/jbt.22982
Abstract: Ischemic stroke is one of the main causes of death and disability. Circular RNAs (circRNAs) have received extensive attention in the pathogenesis of ischemic stroke. Here, we evaluated the role of circCDC14A in cerebral ischemia‐reperfusion… read more here.
Keywords: circcdc14a; cerebral ischemia; ischemia reperfusion; injury ... See more keywords
Silybin phytosome attenuates cerebral ischemia‐reperfusion injury in rats by suppressing oxidative stress and reducing inflammatory response: In vivo and in silico approaches
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23073
Abstract: The present study was aimed to develop silybin phytosome (SIBP) and evaluate its effectiveness against cerebral ischemia‐reperfusion (CIR) injury in rats. Initially, SIBP was prepared and characterized with Fourier transform‐infrared spectroscopy, differential scanning calorimetry, and… read more here.
Keywords: silybin phytosome; cerebral ischemia; treatment; injury ... See more keywords
MicroRNA‐454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting NADPH oxidase 4 (NOX4)
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DOI: 10.1002/jbt.23153
Abstract: To investigate the function of miR‐454 in ischemic stroke, this study was carried out. Cerebral ischemia/reperfusion (I/R) injury animal model and a SHSY5Y cell culture model of oxygen‐glucose deprivation/reoxygenation (OGD/R) were constructed. The effects of… read more here.
Keywords: reperfusion injury; mir 454; cerebral ischemia; injury ... See more keywords
Transplantation with hypoxia‐preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24025
Abstract: Cardiac arrest–induced global cerebral ischemia is a main cause of neurological dysfunction in emergency medicine. Transplantation with bone marrow mesenchymal stem cells (MSCs) has been used in stroke models to repair the ischemic brain injury,… read more here.
Keywords: arrest induced; cerebral ischemia; cardiac arrest; induced global ... See more keywords
QSM in canine model of acute cerebral ischemia: A pilot study
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DOI: 10.1002/mrm.28498
Abstract: In the present study, we investigated the potential of QSM to assess the physiological state of cortical tissue in the middle cerebral artery occlusion canine model of a cerebral ischemia. read more here.
Keywords: cerebral ischemia; canine model; study;
Trilobatin promotes angiogenesis after cerebral ischemia–reperfusion injury via SIRT7/VEGFA signaling pathway in rats
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DOI: 10.1002/ptr.7487
Abstract: Angiogenesis plays a pivotal role in the recovery of neurological function after ischemia stroke. Herein, we investigated the effect of trilobatin (TLB) on angiogenesis after cerebral ischemia–reperfusion injury (CIRI). The effect of TLB on angiogenesis… read more here.
Keywords: ischemia; cerebral ischemia; angiogenesis cerebral; sirt7 vegfa ... See more keywords
Ultra-early Detection of Microcirculatory Injury as Predictor of Developing Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neuroradiology"
DOI: 10.1007/s00062-017-0616-6
Abstract: PurposeDelayed cerebral ischemia (DCI) still remains a major complication after subarachnoid hemorrhage (SAH). The aim of our study was to evaluate whether flow analysis of admission digital subtraction angiography (DSA) using parametric color coding (PCC), a postprocessing… read more here.
Keywords: dci; dci group; cerebral ischemia; subarachnoid hemorrhage ... See more keywords