Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23070
Abstract: Activating transcription factor 4 (ATF4) is known to play an important role in cerebral ischemia through apoptosis and neuron regulation. Histone demethylase JMJD3, specifically removing the methylation of H3K27me3, is highlighted to attenuate cerebral ischemic… read more here.
Keywords: expression; jmjd3; atf4; ischemic injury ... See more keywords
Comparative efficacy and safety of antiplatelet agents in cerebral ischemic disease: A network meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26065
Abstract: We performed a network meta‐analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different antiplatelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes… read more here.
Keywords: cerebral ischemic; efficacy safety; safety; network meta ... See more keywords
Procyanidins exhibits neuroprotective activities against cerebral ischemia reperfusion injury by inhibiting TLR4-NLRP3 inflammasome signal pathway
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05610-z
Abstract: Ischemic stroke is a serious cardiovascular disease with high morbidity and mortality rates that affects millions of people worldwide.Currently, the only therapy with proven efficacy for acute ischemic stroke is alteplase, however, it still has… read more here.
Keywords: cerebral ischemic; procyanidins exhibits; reperfusion; effect ... See more keywords
Salidroside-pretreated mesenchymal stem cells contribute to neuroprotection in cerebral ischemic injury in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular histology"
DOI: 10.1007/s10735-021-10022-0
Abstract: Mesenchymal stem cells (MSCs) are considered a promising tool for treating cerebral ischemic injury. However, their poor survival after transplantation limits their therapeutic effect and applications. Salidroside has been reported to exert potent cytoprotective and… read more here.
Keywords: cerebral ischemic; ischemic injury; mscs; stem cells ... See more keywords
Neuroprotective Effects of Lycium barbarum Polysaccharide on Focal Cerebral Ischemic Injury in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2293-x
Abstract: Increasing evidence demonstrates inflammation contributes to neuronal death following cerebral ischemia. Lycium barbarum polysaccharide (LBP) has been reported to prevent scopolamine-induced cognitive and memory deficits. We recently indicated that LBP exerts neuroprotective effect against focal… read more here.
Keywords: cerebral ischemic; ischemic injury; focal cerebral; injury mice ... See more keywords
Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical Research"
DOI: 10.1007/s11064-021-03500-0
Abstract: Cerebral ischemia is one of the most devastating brain injuries and a primary cause of acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at both the experimental and clinical levels, options for stroke-related brain… read more here.
Keywords: injury; pathways cerebral; mechanistic insight; cerebral ischemic ... See more keywords
Preclinical Development of a Prophylactic Neuroprotective Therapy for the Preventive Treatment of Anticipated Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0532-8
Abstract: Ischemia-reperfusion brain injury can be iatrogenically induced secondary to life-saving procedures. Prophylactic treatment of these patients offers a promising prevention for lifelong complications. We postulate that a cytosine-guanine (CpG) oligodeoxynucleotide (ODN) can provide robust antecedent… read more here.
Keywords: cerebral ischemic; treatment; ischemic injury; ischemia reperfusion ... See more keywords
Safety and Efficacy of Sovateltide (IRL-1620) in a Multicenter Randomized Controlled Clinical Trial in Patients with Acute Cerebral Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2021 at "CNS Drugs"
DOI: 10.1007/s40263-020-00783-9
Abstract: Background Sovateltide (IRL-1620, PMZ-1620), an endothelin-B receptor agonist, has been previously shown to increase cerebral blood flow, have anti-apoptotic activity and produce neurovascular remodeling when administered intravenously following acute cerebral ischemic stroke in rats. Its… read more here.
Keywords: cerebral ischemic; ischemic stroke; acute cerebral; group ... See more keywords
Sodium influx through cerebral sodium‐glucose transporter type 1 exacerbates the development of cerebral ischemic neuronal damage
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.007
Abstract: Abstract We recently reported that cerebral sodium‐glucose transporter type 1 (SGLT‐1) plays a role in exacerbation of cerebral ischemia. However, the mechanism by which cerebral SGLT‐1 acts remains unclear. Here we demonstrated that sodium influx… read more here.
Keywords: cerebral ischemic; neuronal damage; glucose; sodium ... See more keywords
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108718
Abstract: BACKGROUND Perilipin 5 (Plin5) acts as a pivotal mediator of oxidative stress and inflammation and is associated with the progression of relevant diseases. Cerebral ischemic stroke is a severe pathological condition that involves excess oxidative… read more here.
Keywords: ischemic stroke; oxidative stress; plin5; cerebral ischemic ... See more keywords
Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.02.016
Abstract: Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear. In peripheral tissue, the activation of mitogen-activated protein kinases (MAPKs)… read more here.
Keywords: cerebral ischemic; kinase; cerebral ischemia; cerebral sodium ... See more keywords