Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202944
Abstract: Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum enables their sequestration via attachment to the microvasculature. This artificially increases the dwelling time of the infected red blood cells within inner organs… read more here.
Keywords: plasmodium falciparum; neuronal implications; malaria neuronal; implications plasmodium ... See more keywords
In vivo noninvasive visualization of retinal perfusion dysfunction in murine cerebral malaria by camera-phone laser speckle imaging.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biophotonics"
DOI: 10.1002/jbio.201800098
Abstract: Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection associated with impaired cerebral blood flow. Visualization of the eye vasculature, which is embryologically derived from that of the brain, is used clinically to… read more here.
Keywords: camera phone; infection; phone; laser speckle ... See more keywords
microRNA‐27a and microRNA‐146a SNP in cerebral malaria
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.529
Abstract: During Plasmodium falciparum infection, microRNA expression alters in brain tissue of mice with cerebral malaria compared to noninfected controls. MicroRNA regulates gene expression post‐transcriptionally to influence biological processes. Cerebral malaria pathology caused mainly by the… read more here.
Keywords: 146a snp; 27a microrna; microrna 146a; microrna 27a ... See more keywords
Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei
Sign Up to like & getrecommendations! Published in 2018 at "Mammalian Genome"
DOI: 10.1007/s00335-018-9752-9
Abstract: Malaria is a common and sometimes fatal disease caused by infection with Plasmodium parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium falciparum parasites which features a complex immunopathology that includes… read more here.
Keywords: cerebral malaria; model; mouse model; plasmodium berghei ... See more keywords
A simple quinoline salt derivative is active in vitro against plasmodium Faciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109848
Abstract: Chloroquine (CQ) was the most effective and widely used drug for the prophylaxis and treatment of severe and non-severe malaria. Although its prophylactic use has led to resistance to P. falciparum in all endemic countries,… read more here.
Keywords: development; simple quinoline; vitro; quinoline salt ... See more keywords
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108170
Abstract: The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate mutase (BPGM) acts… read more here.
Keywords: deficiency protects; bisphosphoglycerate mutase; protects cerebral; cerebral malaria ... See more keywords
Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline.
Sign Up to like & getrecommendations! Published in 2018 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2016.06.001
Abstract: Malaria-related hemophagocytic lymphohistiocytosis is a rare, potentially fatal, hyperinflammatory disease entity which can be challenging to diagnose and treat. It is usually associated with Plasmodium falciparum infection. It is less frequently associated with Plasmodium vivax.… read more here.
Keywords: lymphohistiocytosis; plasmodium vivax; hemophagocytic lymphohistiocytosis; cerebral malaria ... See more keywords
Interleukin‐15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin‐10‐Producing Natural Killer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.03.012
Abstract: SUMMARY Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells. During experimental cerebral malaria (ECM), mice inoculated with Plasmodium berghei ANKA‐infected red… read more here.
Keywords: cerebral malaria; cd8 cell; treatment; interleukin complex ... See more keywords
AMP-activated protein kinase (AMPK) is decreased in the mouse brain during experimental cerebral malaria
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.10.054
Abstract: Cerebral malaria (CM) is a severe form of malaria caused by Plasmodium falciparum and P.vivax. CM affects the brain leading to coma and is the leading cause of death in malaria patients. The enzyme, adenosine… read more here.
Keywords: activated protein; ampk; protein kinase; cerebral malaria ... See more keywords
Cytotoxic T Lymphocyte Granzyme-b mediates neuronal cell death during Plasmodium berghei ANKA induced experimental cerebral malaria
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.021
Abstract: Cerebral malaria is a complex, acute, neurological disease characterised by a sudden onset of cerebral symptoms. This disease is manifested as initial arousable stage that is followed by an unarousable coma and eventually death. Parasite… read more here.
Keywords: death; cytotoxic lymphocyte; granzyme; experimental cerebral ... See more keywords
Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00123
Abstract: Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to… read more here.
Keywords: uncomplicated severe; severe malaria; host metabolic; cerebral malaria ... See more keywords