Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205786120
Abstract: Stroke-induced cerebral microvascular dysfunction contributes to aggravation of neuronal injury and compromises the efficacy of current reperfusion therapies. Understanding the molecular alterations in cerebral microvessels in stroke will provide original opportunities for scientific investigation of… read more here.
Keywords: stroke induced; cerebral microvascular; cerebral microvasculature; stroke ... See more keywords
Arteriolar neuropathology in cerebral microvascular disease
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12875
Abstract: Cerebral microvascular disease (MVD) is an important cause of vascular cognitive impairment. MVD is heterogeneous in aetiology, ranging from universal ageing to the sporadic (hypertension, sporadic cerebral amyloid angiopathy [CAA] and chronic kidney disease) and… read more here.
Keywords: microvascular disease; disease; neuropathology; cerebral microvascular ... See more keywords
Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-249156
Abstract: A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow… read more here.
Keywords: matter; white matter; severe covid; infection ... See more keywords
Effects of Hypoxia on Cerebral Microvascular Angiogenesis: Benefits or Damages?
Sign Up to like & getrecommendations! Published in 2023 at "Aging and Disease"
DOI: 10.14336/ad.2022.0902
Abstract: Cerebrovascular microcirculation is essential for maintaining the physiological functions of the brain. The brain can be protected from stress injury by remodeling the microcirculation network. Angiogenesis is a type of cerebral vascular remodeling. It is… read more here.
Keywords: microcirculation; effects hypoxia; cerebral microvascular; blood ... See more keywords
Panax notoginseng Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecules"
DOI: 10.3390/molecules23112781
Abstract: Oxidative stress plays a critical role in cerebral ischemia/reperfusion (I/R)-induced blood-brain barrier (BBB) disruption. Panax notoginseng saponins (PNS) possess efficient antioxidant activity and have been used in the treatment of cerebral ischemic stroke in China.… read more here.
Keywords: notoginseng saponins; panax notoginseng; cerebral microvascular; reperfusion ... See more keywords