Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205786120
Abstract: Stroke-induced cerebral microvascular dysfunction contributes to aggravation of neuronal injury and compromises the efficacy of current reperfusion therapies. Understanding the molecular alterations in cerebral microvessels in stroke will provide original opportunities for scientific investigation of… read more here.
Keywords: stroke induced; cerebral microvascular; cerebral microvasculature; stroke ... See more keywords
Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke
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DOI: 10.1155/2021/5281182
Abstract: Pericyte, as an important component of the blood-brain barrier, has received increasing attention in the study of cerebrovascular diseases. However, the mechanism of pericytes after the occurrence of cerebral ischemia is controversial. On the one… read more here.
Keywords: pericytes cerebral; microvasculature different; time points; cerebral microvasculature ... See more keywords
The Effect of Hypercholesterolemia on the Characteristics of Cerebral Microvasculature
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DOI: 10.2337/db18-463-p
Abstract: Aim: It remains unclear whether the increase of LDL cholesterol (LDL-C) is a risk factor for cerebral vascular disease (CVD). To clarify the effects of hypercholesterolemia on cerebral small vessel disease (SVD), we investigate the… read more here.
Keywords: characteristics cerebral; vessel wall; prevalence; cerebral microvasculature ... See more keywords
Guhong Injection Protects Against Apoptosis in Cerebral Ischemia by Maintaining Cerebral Microvasculature and Mitochondrial Integrity Through the PI3K/AKT Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.650983
Abstract: Guhong injection (GHI) can be used for the treatment of ischemic stroke. We investigated the antiapoptotic activity of GHI, its ability to repair the cerebral microvessels and mitochondria, and the PI3K/AKT signaling pathway of GHI… read more here.
Keywords: cerebral microvasculature; microscopy; guhong injection; pi3k akt ... See more keywords