Single Cerebral Organoid Mass Spectrometry of Cell-Specific Protein and Glycosphingolipid Traits
Sign Up to like & getrecommendations! Published in 2023 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c00981
Abstract: Cerebral organoids are a prolific research topic and an emerging model system for neurological diseases in human neurobiology. However, the batch-to-batch reproducibility of current cultivation protocols is challenging and thus requires a high-throughput methodology to… read more here.
Keywords: mass spectrometry; single cerebral; cell; cerebral organoid ... See more keywords
Lineage recording in human cerebral organoids
Sign Up to like & getrecommendations! Published in 2021 at "Nature Methods"
DOI: 10.1038/s41592-021-01344-8
Abstract: Induced pluripotent stem cell (iPSC)-derived organoids provide models to study human organ development. Single-cell transcriptomics enable highly resolved descriptions of cell states within these systems; however, approaches are needed to directly measure lineage relationships. Here… read more here.
Keywords: development; recording human; cerebral organoid; cerebral organoids ... See more keywords
A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry
Sign Up to like & getrecommendations! Published in 2021 at "Micromachines"
DOI: 10.3390/mi12121574
Abstract: Mental disorders have high prevalence, but the efficacy of existing therapeutics is limited, in part, because the pathogenic mechanisms remain enigmatic. Current models of neural circuitry include animal models and post-mortem brain tissue, which have… read more here.
Keywords: connectivity; cerebral organoid; circuitry; tract ... See more keywords