Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13389
Abstract: It is currently challenging to adequately model the growth and migration of glioblastoma using two‐dimensional (2D) in vitro culture systems as they quickly lose the original, patient‐specific identity and heterogeneity. However, with the advent of… read more here.
Keywords: cell; glioblastoma; cerebral organoids; migration ... See more keywords
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02361-9
Abstract: APOE4 is a strong genetic risk factor for Alzheimer’s disease and Dementia with Lewy bodies; however, how its expression impacts pathogenic pathways in a human-relevant system is not clear. Here using human iPSC-derived cerebral organoid… read more here.
Keywords: pathology; cerebral organoids; derived cerebral; ipsc derived ... See more keywords
Modeling cell-cell interactions in the brain using cerebral organoids
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146458
Abstract: Until recently, a great amount of brain studies have been conducted in human post mortem tissues, cell lines and model organisms. These researches provided useful insights regarding cell-cell interactions occurring in the brain. However, such… read more here.
Keywords: cell interactions; cell; modeling cell; cerebral organoids ... See more keywords
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.047
Abstract: The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain development and disease. Accordingly, considerable attention has been placed on the development… read more here.
Keywords: self organized; organized cerebral; cerebral organoids; zika virus ... See more keywords
Glioblastoma Model Using Human Cerebral Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.105
Abstract: SUMMARY We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations. We used CRISPR/Cas9 technology to target an HRasG12V-IRES-tdTomato construct… read more here.
Keywords: glioblastoma model; model using; cerebral organoids; human cerebral ... See more keywords
Age selective segregation of peroxisomes couples with mitotic spindle in stem like cells division
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.463
Abstract: and oligodendrocyte precursors as adherent cells. Based on high expression level of Pax6, Sox1, Sox2 and low expression of Pax3 NESCs likely have primitive neural plate identity. Besides spontaneous differentiation in adherent culture, hNESCs are… read more here.
Keywords: peroxisomes couples; age selective; cerebral organoids; segregation peroxisomes ... See more keywords
Wnt pathway activation in 3D nephron progenitor culture facilitates self-organization, expansion, and differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.465
Abstract: and oligodendrocyte precursors as adherent cells. Based on high expression level of Pax6, Sox1, Sox2 and low expression of Pax3 NESCs likely have primitive neural plate identity. Besides spontaneous differentiation in adherent culture, hNESCs are… read more here.
Keywords: expansion; cerebral organoids; differentiation; activation ... See more keywords
Induction of Expansion and Folding in Human Cerebral Organoids.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.11.017
Abstract: An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. It has been suggested that an increase in the proliferative potential of neural progenitors (NPs) underlies… read more here.
Keywords: expansion folding; folding human; expansion; induction expansion ... See more keywords
How cerebral organoids are guiding brain-cancer research and therapies
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-06708-3
Abstract: To find better treatments for brain cancer, an important step might be to grow mini-brains in the lab.To find better treatments for brain cancer, an important step might be to grow mini-brains in the lab. read more here.
Keywords: brain cancer; organoids guiding; cerebral organoids; guiding brain ... See more keywords
Fused cerebral organoids model interactions between brain regions
Sign Up to like & getrecommendations! Published in 2017 at "Nature Methods"
DOI: 10.1038/nmeth.4304
Abstract: Human brain development involves complex interactions between different regions, including long-distance neuronal migration or formation of major axonal tracts. Different brain regions can be cultured in vitro within 3D cerebral organoids, but the random arrangement… read more here.
Keywords: brain regions; cerebral organoids; organoids model; fused cerebral ... See more keywords
Modeling amyloid beta and tau pathology in human cerebral organoids
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0229-8
Abstract: The typical abnormalities observed in the brain of Alzheimer’s disease (AD) patients include synaptic alterations, neuronal death, brain inflammation, and the accumulation of protein aggregates in the form of amyloid plaques and neurofibrillary tangles. Despite… read more here.
Keywords: amyloid beta; pathology; beta tau; cerebral organoids ... See more keywords