RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation
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DOI: 10.1016/j.nbd.2021.105396
Abstract: Cerebrovascular remodeling is the most common cause of hypertension and stroke. Ubiquitin E3 ligase RING finger protein 34 (RNF34) is suggested to be associated with the development of multiple neurological diseases. However, the importance of… read more here.
Keywords: remodeling hypertension; rnf34; ros generation; derived ros ... See more keywords
Low Chloride–Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.121.18472
Abstract: Background: Low serum chloride (Cl−) level is considered an independent predictor of cardiovascular mortality associated with chronic hypertension. However, the underlying mechanisms are unknown. ClC-5, a member of the Cl− channel family, is sensitive to… read more here.
Keywords: cell; cerebrovascular remodeling; proliferation; hypertension ... See more keywords