Functional characterization of Polr3a hypomyelinating leukodystrophy mutations in the S. cerevisiae homolog, RPC160.
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DOI: 10.1016/j.gene.2020.145259
Abstract: Mutations in RNA polymerase III (Pol III) cause hypomeylinating leukodystrophy (HLD) and neurodegeneration in humans. POLR3A and POLR3B, the two largest Pol III subunits, together form the catalytic center and carry the majority of disease… read more here.
Keywords: iii; homolog rpc160; leukodystrophy; cerevisiae homolog ... See more keywords