Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.
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DOI: 10.1016/j.lfs.2022.120446
Abstract: Changes in sphingolipid metabolism regulate and/or alter many cellular functions in the brain. Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to ceramide-1-phosphate (C1P) by ceramide kinase (CerK). CerK and C1P were reported to… read more here.
Keywords: ceramide kinase; brain; cerk; loss ... See more keywords
Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells
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DOI: 10.3390/cancers14184496
Abstract: Simple Summary Existing chemotherapy treatments for breast cancer patients are high on toxicity. There are very limited options available for triple-positive breast cancer (TPBC) patients, and there have not been any major breakthrough for targeted… read more here.
Keywords: cell; cerk; triple positive; breast cancer ... See more keywords