Using RNA sequencing to identify a putative lncRNA-associated ceRNA network in laryngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1741282
Abstract: ABSTRACT Accumulating evidence indicates that lncRNAs can interact with miRNAs to regulate target mRNAs through competitive interactions. However, this mechanism remains largely unexplored in laryngeal squamous cell carcinoma (LSCC). In this study, transcriptome-wide RNA sequencing… read more here.
Keywords: cell; network; cell carcinoma; squamous cell ... See more keywords
Systematic review of computational methods for identifying miRNA-mediated RNA-RNA crosstalk
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbx137
Abstract: Posttranscriptional crosstalk and communication between RNAs yield large regulatory competing endogenous RNA (ceRNA) networks via shared microRNAs (miRNAs), as well as miRNA synergistic networks. The ceRNA crosstalk represents a novel layer of gene regulation that… read more here.
Keywords: rna; cerna; cerna regulation; crosstalk ... See more keywords
LnCeCell: a comprehensive database of predicted lncRNA-associated ceRNA networks at single-cell resolution
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1017
Abstract: Abstract Within the tumour microenvironment, cells exhibit different behaviours driven by fine-tuning of gene regulation. Identification of cellular-specific gene regulatory networks will deepen the understanding of disease pathology at single-cell resolution and contribute to the… read more here.
Keywords: single cell; lncecell; cerna; lncrna associated ... See more keywords
Bioinformatic analysis of differentially expressed profiles of lncRNAs and miRNAs with their related ceRNA network in endometrial cancer
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000032573
Abstract: Increasing evidence suggests that long non-coding riboneucleic acids (lncRNAs), as competing endogenous RNA (ceRNA), play a key role in the initiation, invasion, and metastasis of cancer. As a new hypothesis, the lncRNA-micro RNA (miRNA)-messenger RNA… read more here.
Keywords: network; cerna; differentially expressed; lncrnas mirnas ... See more keywords
Constructing Integrative Cerna Networks and Finding Prognostic Biomarkers in Renal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2022.3214190
Abstract: Inspired by a newly discovered gene regulation mechanism known as competing endogenous RNA (ceRNA) interactions, several computational methods have been proposed to generate ceRNA networks. However, most of these methods have focused on deriving restricted… read more here.
Keywords: cell carcinoma; renal cell; prognostic biomarkers; cerna ... See more keywords
Pseudogenes regulate parental gene expression via ceRNA network
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.12952
Abstract: The concept of competitive endogenous RNA (ceRNA) was first proposed by Salmena and colleagues. Evidence suggests that pseudogene RNAs can act as a ‘sponge’ through competitive binding of common miRNA, releasing or attenuating repression through… read more here.
Keywords: parental gene; network; gene expression; cerna ... See more keywords
Comprehensive Analysis of ceRNA Regulation Network Involved in the Development of Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/6658115
Abstract: Background Coronary artery disease (CAD) is one of the most common causes of sudden death with high morbidity in recent years. This paper is aimed at exploring the early peripheral blood biomarkers of sudden death… read more here.
Keywords: network; coronary artery; cerna; cerna regulation ... See more keywords
The ceRNA Crosstalk between mRNAs and lncRNAs in Diabetes Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/4283534
Abstract: Competitive endogenous RNA regulation suggests an intricate network of all transcriptional RNAs that have the function of repressing miRNA function and regulating mRNA expression. Today, the specific ceRNA regulatory mechanisms of lncRNA–miRNA–mRNA in patients who… read more here.
Keywords: network; mirna mrna; cerna; myocardial infarction ... See more keywords
High-throughput validation of ceRNA regulatory networks
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-3790-7
Abstract: BackgroundMicroRNAs (miRNAs) play multiple roles in tumor biology. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive stoichiometric sequestration. Specifically, computational models predicted and experimental assays confirmed that miRNA activity… read more here.
Keywords: mirna targets; cerna; throughput validation; validation cerna ... See more keywords
Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6321-x
Abstract: A long noncoding RNA (lncRNA) can act as a competing endogenous RNA (ceRNA) to compete with an mRNA for binding to the same miRNA. Such an interplay between the lncRNA, miRNA, and mRNA is called… read more here.
Keywords: rna; cerna; seq data; mutual information ... See more keywords
Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02279-y
Abstract: Background To detect the development, function and therapeutic potential of epicardial adipose tissue (EAT); analyze a related gene expression dataset, including data from neonates, infants, and children with congenital heart disease (CHD); compare the data… read more here.
Keywords: epicardial adipose; heart; infiltration; analysis ... See more keywords