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   Articles with "cers6" as a keyword



CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1

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recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02727-y

Abstract: Esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis because it is typically diagnosed at a moderate or advanced stage. Investigating the precise molecular mechanism of ESCC pathogenesis is essential for developing new therapeutic… read more here.

Keywords: esophageal squamous; rpn1; cell; squamous cell ... See more keywords

The effects of restraint stress on ceramide metabolism disorders in the rat liver: the role of CerS6 in hepatocyte injury

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recommendations! Published in 2024 at "Lipids in Health and Disease"

DOI: 10.1186/s12944-024-02019-x

Abstract: Background Stress is implicated in various pathological conditions leading to liver injury. Existing evidence suggests that excessive stress can induce mitochondrial damage in hepatocytes, yet the underlying mechanism remains unclear. Ceramide synthase 6 (CerS6)-derived C16:0… read more here.

Keywords: stress; cort; mitochondrial damage; ceramide ... See more keywords

IGF2BP3 worsens lung cancer through modifying long non-coding RNA CERS6-AS1/microRNA-1202 axis.

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recommendations! Published in 2022 at "Current medicinal chemistry"

DOI: 10.2174/0929867329666220614091445

Abstract: BACKGROUND Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) can epigenetically regulate lung cancer progression, but its regulatory mechanism in the disease lacks sufficient exploration. OBJECTIVE The study was conducted to probe the regulatory function… read more here.

Keywords: lung cancer; cers6 as1; mir 1202; cers6 ... See more keywords

C16‑ceramide and sphingosine 1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.

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recommendations! Published in 2018 at "Oncology reports"

DOI: 10.3892/or.2018.6689

Abstract: Recently, sphingolipid derivatives, such as ceramide and sphingosine‑1‑phosphate (S1P), have emerged as key modulators in apoptotic cell death and cell proliferation. This study aimed to clarify the underlying signaling pathways of ceramide and S1P involved… read more here.

Keywords: cers6; cell proliferation; ceramide; mtor ... See more keywords