Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.12978
Abstract: Little is known about the iron efflux mechanism in adipocytes. Here, we used hephaestin (Heph) and ceruloplasmin (Cp) single‐knockout (KO) mice and Heph/Cp double‐KO mice to investigate the roles of multicopper ferroxidases (MCFs) in this… read more here.
Keywords: ablation hephaestin; hephaestin ceruloplasmin; type diabetes; ceruloplasmin ... See more keywords
High Serum Copper Readings Have Precedent and Do Not Generally Indicate Copper Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Obesity Surgery"
DOI: 10.1007/s11695-021-05835-7
Abstract: An article published in Obesity Surgery [1] reports serum copper findings for a New Orleans bariatric surgery site. High serum copper values are reported for 26% of the obese patients going through workup for bariatric… read more here.
Keywords: high serum; copper; serum; serum copper ... See more keywords
Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.04.005
Abstract: BACKGROUND Ceruloplasmin (CP) may promote structural changes in the atrium making it more arrhythmogenic. We assessed the associations between CP, CP-associated genetic variants, and incident atrial fibrillation (AF) in the Atherosclerosis Risk in Communities (ARIC)… read more here.
Keywords: atrial fibrillation; risk; risk communities; atherosclerosis risk ... See more keywords
Elevated microRNA-520d-5p in the serum of patients with Parkinson's disease, possibly through regulation of cereloplasmin expression
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.09.034
Abstract: Iron metabolism dysfunction and redox-active iron-induced oxidative stress in the brain may contribute to the pathogenesis of Parkinson's disease. We have previously demonstrated that reduced serum ceruloplasmin level exacerbates nigral iron deposition in Parkinson's disease,… read more here.
Keywords: mir 520d; disease; serum; expression ... See more keywords
How do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2089650
Abstract: Abstract Objectives We aimed to examine the change in plasma copper (Cu) level and copper transport proteins level before inserting Cu-IUD and after one menstrual cycle and to show the effect of this change on… read more here.
Keywords: copper; thiol disulfide; disulfide balance; ceruloplasmin ... See more keywords
Ceruloplasmin-Deficient Mice Show Dysregulation of Lipid Metabolism in Liver and Adipose Tissue Reduced by a Protein Replacement
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021150
Abstract: Ceruloplasmin is a ferroxidase that plays a role in iron homeostasis; its deficiency fosters inter alia iron accumulation in the liver, which expresses the soluble form of the protein secreted into the bloodstream. Ceruloplasmin is… read more here.
Keywords: replacement; iron; adipose tissue; ceruloplasmin ... See more keywords
Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Biochemistry"
DOI: 10.5937/jomb0-37597
Abstract: Background Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). The diagnostic gold standard for detecting NASH still relies upon an invasive pathological biopsy. There is, therefore, a need to identify… read more here.
Keywords: iron metabolism; ceruloplasmin; serum ceruloplasmin;