Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral‐host interaction with implications for disease intervention
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33033
Abstract: HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub‐Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity,… read more here.
Keywords: african ancestry; cervical carcinogenesis; hpv35; hpv35 cervical ... See more keywords
Comparative transcriptomic profiling in HPV-associated cervical carcinogenesis: Implication of MHC class II and immunoglobulin heavy chain genes.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118026
Abstract: AIM We aimed to determine the biological processes and pathways involved in cervical carcinogenesis associated with high-risk human papillomavirus (HPV) infection. MATERIALS AND METHODS Total RNA was extracted from three formalin-fixed paraffin-embedded (FFPE) samples each… read more here.
Keywords: immunoglobulin heavy; hpv; cervical carcinogenesis; transcriptomic profiling ... See more keywords
Co-infections of HPV16/18 with other high-risk HPV types and the risk of cervical carcinogenesis: A large population-based study.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.10.003
Abstract: OBJECTIVE Human papillomavirus (HPV) 16/18 genotyping is an effective method for triage of high-risk (hr) HPV-positive women in primary hrHPV screening for cervical cancer. The present study aimed to evaluate whether co-infected with other hrHPV… read more here.
Keywords: risk; cervical carcinogenesis; hpv16 infection; risk cervical ... See more keywords
The application of CRISPR/Cas9 system in cervical carcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00366-w
Abstract: Integration of high-risk HPV genomes into cellular chromatin has been confirmed to promote cervical carcinogenesis, with HPV16 being the most prevalent high-risk type. Herein, we evaluated the therapeutic effect of the CRISPR/Cas9 system in cervical… read more here.
Keywords: crispr cas9; hpv16; cervical carcinogenesis;
O05.6 Cervicovaginal metabolic profiling reveals the interplay between HPV, microbiota and inflammation in cervical carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.133
Abstract: Background Vaginal dysbiosis has emerged as a key risk factor in HPV acquisition, persistence, and potentially cervical carcinogenesis. However, the biological mechanisms driving persistence and carcinogenesis have not been elucidated. Hence, our objective was to… read more here.
Keywords: metabolic profiles; cervical carcinogenesis; metabolic profiling; inflammation ... See more keywords
Expression of Ezrin and Estrogen Receptors During Cervical Carcinogenesis
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DOI: 10.1177/1933719116667222
Abstract: Rationale: Development of cervical squamous carcinoma (CXCA) is accompanied by changes in estrogen receptors (ERs, ERα and ERβ) and ezrin expression; however, reports have been conflicting. Using histologically documented staging of cervical biopsies, we determined… read more here.
Keywords: estrogen receptors; cxca; expression; cervical carcinogenesis ... See more keywords
High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Epidemiology"
DOI: 10.2188/jea.je20200142
Abstract: Background Inflammation is emerging as a potential mechanism of cervical carcinogenesis. However, few studies have investigated the association between host inflammatory status and the natural course of cervical precursor lesion. The aim of this study… read more here.
Keywords: regression; lsil regression; cervical carcinogenesis; low grade ... See more keywords
CD74 and HLA-DRA in Cervical Carcinogenesis: Potential Targets for Antitumour Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58020190
Abstract: Background and Objectives: Abnormal expressions of CD74 and human leukocyte antigen-DR alpha (HLA-DRA) have been reported in various cancers, though their roles in cervical cancer remain unclear. This study aimed to evaluate the gene and… read more here.
Keywords: cervical carcinogenesis; cin; hla dra; cd74 hla ... See more keywords