Carbonate‐Based Fluorescent Chemical Tool for Uncovering Carboxylesterase 1 (CES1) Activity Variations in Live Cells
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200069
Abstract: Carboxylesterase 1 (CES1) plays a key role in the metabolism of endogenous biomolecules and xenobiotics including a variety of pharmaceuticals. Despite the established importance of CES1 in drug metabolism, methods to study factors that can… read more here.
Keywords: carboxylesterase ces1; live cells; activity; ces1 ... See more keywords
The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13237
Abstract: AIMS This study investigated the influence of CES1 variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate. METHODS CES1… read more here.
Keywords: 143e allele; ces1 copies; group; healthy danish ... See more keywords
A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.077669
Abstract: Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the metabolism of many clinically important medications. CES1 expression and activity vary markedly among individuals; and genetic variation is a major contributing factor to… read more here.
Keywords: functional assessment; assessment carboxylesterase; carboxylesterase; ces1 ... See more keywords
CES1 and SLC6A2 Genetic Variants As Predictors of Response To Methylphenidate in Autism Spectrum Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s377210
Abstract: Purpose Autistic spectrum disorders (ASD) children and adolescents usually present comorbidities, with 40–70% of them affected by attention deficit hyperactivity disorders (ADHD). The first option of pharmacological treatment for these patients is methylphenidate (MPH). ASD… read more here.
Keywords: mph; asd children; spectrum disorders; side effects ... See more keywords
Genetic Analysis Reveals a Significant Contribution of CES1 to Prostate Cancer Progression in Taiwanese Men
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051346
Abstract: The genes that influence prostate cancer progression remain largely unknown. Since the carboxylesterase gene family plays a crucial role in xenobiotic metabolism and lipid/cholesterol homeostasis, we hypothesize that genetic variants in carboxylesterase genes may influence… read more here.
Keywords: cancer; ces1; prostate cancer; cancer progression ... See more keywords
The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061192
Abstract: Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify the influence of polymorphisms of the genes encoding P-glycoprotein (ABCB1) and carboxylesterase 1 (CES1)… read more here.
Keywords: plasma concentrations; kazakhstani patients; ces1; atrial fibrillation ... See more keywords
The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040580
Abstract: The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). Previous studies show that variant rs71647871 in the CES1 gene affects the pharmacokinetics of enalapril on… read more here.
Keywords: arterial hypertension; patients arterial; pharmacokinetics enalapril; influence ces1 ... See more keywords