CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101426
Abstract: Objective Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects,… read more here.
Keywords: expression; epoxide hydrolase; regulatory loop; pdac ... See more keywords
Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03309g
Abstract: Carboxylesterase 2 (CES2) has crucial roles in both xenobiotic metabolism and formation of pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 activity in living cancer cells. Here, we report a… read more here.
Keywords: cancer cells; ces2; carboxylesterase; activity ... See more keywords
Prognostic and Immunological Roles of CES2 in Breast Cancer and Potential Application of CES2-Targeted Fluorescent Probe DDAB in Breast Surgery
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s406835
Abstract: Purpose The expression and function of CES2 in breast cancer (BRCA) has not been fully elucidated. The purpose of this study was to investigate its clinical significance in BRCA. Patients and Methods Bioinformatics analysis tools… read more here.
Keywords: breast; ces2; probe ddab; fluorescent probe ... See more keywords
Covalent CES2 Inhibitors Protect against Reduced Formation of Intestinal Organoids by the Anticancer Drug Irinotecan.
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DOI: 10.2174/1389200224666221212143904
Abstract: BACKGROUND Irinotecan is widely used to treat various types of solid and metastatic cancer. It is an ester prodrug and its hydrolytic metabolite (SN-38) exerts potent anticancer activity. Irinotecan is hydrolyzed primarily by carboxylesterase-2 (CES2),… read more here.
Keywords: covalent ces2; ces2; reduced formation; formation intestinal ... See more keywords
Design and construction of Carboxylesterase 2c Gene knockout Rats by CRISPR/Cas9.
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DOI: 10.2174/1389200224666230123140919
Abstract: BACKGROUND Carboxylesterase 2 (CES2) is mainly distributed in the human liver and gut, and plays an active role in the metabolic activation of many prodrugs and lipid metabolism. Although CES2 is of great significance, there… read more here.
Keywords: crispr cas9; ces2; carboxylesterase; gene knockout ... See more keywords
The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113101
Abstract: Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with respect to their hydrolytic function on (pro)drugs, whereas their physiological role in lipid and energy metabolism has been realized only within the last… read more here.
Keywords: ortholog human; human ces2; structure; potential ortholog ... See more keywords