Articles with "cest" as a keyword



Reproducibility of 3 T APT‐CEST in Healthy Volunteers and Patients With Brain Glioma

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Published in 2022 at "Journal of Magnetic Resonance Imaging"

DOI: 10.1002/jmri.28239

Abstract: Amide proton transfer (APT) imaging is a chemical exchange saturation transfer (CEST) technique offering potential clinical applications such as diagnosis, characterization, and treatment planning and monitoring in glioma patients. While APT‐CEST has demonstrated high potential,… read more here.

Keywords: healthy volunteers; cest; apt cest; reproducibility apt ... See more keywords
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Towards the molecular origin of glutamate CEST (GluCEST) imaging in rat brain

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Published in 2019 at "Magnetic Resonance in Medicine"

DOI: 10.1002/mrm.28021

Abstract: Chemical exchange saturation transfer (CEST) signals at 3 ppm acquired with high irradiation powers, termed GluCEST, have been suggested as an indicator of glutamate in neural systems. However, amines in proteins may also contribute to… read more here.

Keywords: rat brain; cest; molecular origin; towards molecular ... See more keywords

Isolation of Amide Proton Transfer effect and relayed Nuclear Overhauser Enhancement effect at -3.5ppm Using CEST with Double Saturation Powers.

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Published in 2023 at "Magnetic resonance in medicine"

DOI: 10.1002/mrm.29691

Abstract: PURPOSE Quantifications of amide proton transfer (APT) and nuclear Overhauser enhancement (rNOE(-3.5)) mediated saturation transfer with high specificity are challenging because their signals measured in a Z-spectrum are overlapped with confounding signals from direct water… read more here.

Keywords: saturation; transfer; effect; cest ... See more keywords

Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study.

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Published in 2025 at "Magnetic resonance in medicine"

DOI: 10.1002/mrm.70210

Abstract: PURPOSE The aim is to evaluate the effectiveness of timed breathing in reducing respiratory motion artifacts in renal chemical exchange saturation transfer (CEST) MRI and to assess potential differences in CEST effects between renal compartments.… read more here.

Keywords: renal cest; mri; respiratory motion; cest ... See more keywords

Dynamic alteration in myocardium creatine during acute infarction using MR chemical exchange saturation transfer (CEST) imaging.

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Published in 2022 at "NMR in biomedicine"

DOI: 10.1002/nbm.4704

Abstract: Creatine (Cr) is an essential metabolite in the creatine kinase reaction that plays a critical role in maintaining normal cardiac function. Chemical exchange saturation transfer (CEST) MRI offers a novel way to map myocardium Cr.… read more here.

Keywords: cest; creatine; chemical exchange; acute infarction ... See more keywords

Protein and peptide engineering for CEST imaging in the age of Synthetic Biology.

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Published in 2022 at "NMR in biomedicine"

DOI: 10.1002/nbm.4712

Abstract: At the beginning of the millennium, the first Chemical Exchange Saturation Transfer (CEST) contrast agents were bio-organic molecules. However, later, metal based CEST agents (paraCEST agents) took center stage. This didn't last too long as… read more here.

Keywords: synthetic biology; cest contrast; biology; cest agents ... See more keywords

Demonstration of pH imaging in acute stroke with endogenous ratiometric CEST MRI at 2ppm.

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Published in 2022 at "NMR in biomedicine"

DOI: 10.1002/nbm.4850

Abstract: pH change is often considered a hallmark of metabolic disruption in diseases such as ischemic stroke and cancer. Chemical exchange saturation transfer (CEST) MRI, particularly amide proton transfer (APT), has emerged as a noninvasive pH… read more here.

Keywords: ratiometric cest; cest; cest mri; acute stroke ... See more keywords

Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T.

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Published in 2023 at "NMR in biomedicine"

DOI: 10.1002/nbm.4937

Abstract: Chemical exchange saturation transfer (CEST) sensitively detects molecular alterations in the brain, such as relayed nuclear Overhauser effect (rNOE) CEST contrast at -3.5 ppm representing aliphatic protons in both lipids and proteins, and CEST contrast… read more here.

Keywords: cpz; cest; chemical exchange; pathology ... See more keywords

Toward Noninvasive High‐Resolution In Vivo pH Mapping in Brain Tumors by 31P‐Informed deepCEST MRI

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Published in 2025 at "Nmr in Biomedicine"

DOI: 10.1002/nbm.70060

Abstract: The intracellular pH (pHi) is critical for understanding various pathologies, including brain tumors. While conventional pHi measurement through 31P‐MRS suffers from low spatial resolution and long scan times, 1H‐based APT‐CEST imaging offers higher resolution with… read more here.

Keywords: 31p phi; brain tumors; phi; cest ... See more keywords

Enhancing sensitivity of pH-weighted MRI with combination of amide and guanidyl CEST

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Published in 2017 at "NeuroImage"

DOI: 10.1016/j.neuroimage.2017.06.007

Abstract: &NA; Amide‐proton‐transfer weighted (APTw) MRI has emerged as a non‐invasive pH‐weighted imaging technique for studies of several diseases such as ischemic stroke. However, its pH‐sensitivity is relatively low, limiting its capability to detect small pH… read more here.

Keywords: contrast; sensitivity; weighted mri; amide guanidyl ... See more keywords

Attention-Based MultiOffset Deep Learning Reconstruction of Chemical Exchange Saturation Transfer (AMO-CEST) MRI

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Published in 2024 at "IEEE Journal of Biomedical and Health Informatics"

DOI: 10.1109/jbhi.2024.3404225

Abstract: One challenge of chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is the long scan time due to multiple acquisitions of images at different saturation frequency offsets. k-space under-sampling strategy is commonly used to… read more here.

Keywords: deep learning; saturation; amo cest; cest ... See more keywords