Cholesteryl ester transfer protein knock‐down in conjunction with a cholesterol‐depleting agent decreases tamoxifen resistance in breast cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "IUBMB Life"
DOI: 10.1002/iub.2823
Abstract: The cholesterogenic phenotype, encompassing de novo biosynthesis and accumulation of cholesterol, aids cancer cell proliferation and survival. Previously, the role of cholesteryl ester (CE) transfer protein (CETP) has been implicated in breast cancer aggressiveness, but… read more here.
Keywords: cancer; breast cancer; knock; cetp ... See more keywords
Cholesteryl Ester Transfer Protein Impairs Triglyceride Clearance via Androgen Receptor in Male Mice
Sign Up to like & getrecommendations! Published in 2020 at "Lipids"
DOI: 10.1002/lipd.12271
Abstract: Abstract Elevated postprandial triacylglycerols (TAG) are an important risk factor for cardiovascular disease. Men have higher plasma TAG and impaired TAG clearance compared to women, which may contribute to sex differences in risk of cardiovascular… read more here.
Keywords: protein; plasma tag; clearance; cetp ... See more keywords
The lipid substrate preference of CETP controls the biochemical properties of HDL in fat/cholesterol-fed hamsters
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Lipid Research"
DOI: 10.1016/j.jlr.2021.100027
Abstract: Abstract Cholesteryl ester transfer protein (CETP) modulates lipoprotein metabolism by transferring cholesteryl ester (CE) and triglyceride (TG) between lipoproteins. However, differences in the way CETP functions exist across species. Unlike human CETP, hamster CETP prefers… read more here.
Keywords: hamster cetp; cholesterol; human cetp; cetp ... See more keywords
Dyslipidaemia: Is CETP inhibition a viable therapeutic strategy?
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cardiology"
DOI: 10.1038/nrcardio.2017.87
Abstract: LDL The rationale for targeting cholesteryl ester transfer protein (CETP), an enzyme that promotes the transfer of cholesteryl esters from HDL to very low-density lipoprotein and LDL, to reduce the risk of cardiovascular disease is… read more here.
Keywords: hdl levels; trial; disease; cetp inhibition ... See more keywords
Alterations of lipid metabolism, blood pressure and fatty liver in spontaneously hypertensive rats transgenic for human cholesteryl ester transfer protein
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension Research"
DOI: 10.1038/s41440-020-0401-9
Abstract: Cholesteryl ester transfer protein (CETP) mediates a step in reverse cholesterol transport, which channels cholesterol from peripheral tissues back to the liver. Mice and rats are CETP-deficient species, which assumedly contribute to rodent atherosclerosis resistance.… read more here.
Keywords: transfer protein; spontaneously hypertensive; hypertensive rats; cholesteryl ester ... See more keywords
How cholesteryl ester transfer protein can also be a potential triglyceride transporter
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05449-z
Abstract: CETP transfers cholesteryl esters (CEs) and triglycerides (TGs) between different lipoproteins and came in limelight as a drug-target against CVD. In the search for detailed mechanism of lipid transfer through CETP, enormous effort is devoted… read more here.
Keywords: transfer protein; protein also; cholesteryl ester; transfer ... See more keywords
Binding profiles of cholesterol ester transfer protein with current inhibitors: a look at mechanism and drawback
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1363661
Abstract: Although the pharmacological inhibition of cholesterol ester transport protein (CETP) has been proposed as a method of preventing and treating cardiovascular disease (CVD), the adverse effects of current inhibitors have cast doubt on the interaction… read more here.
Keywords: protein; mechanism; cholesterol ester; cetp ... See more keywords
Reliable structural information for rational design of benzoxazole type potential cholesteryl ester transfer protein (CETP) inhibitors through multiple validated modeling techniques
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1552895
Abstract: Abstract The drug design and discovery of lipid modulators is very demanding as no new molecule has entered into the market in the last 35 years. Cholesteryl ester transfer protein (CETP) is a promising target… read more here.
Keywords: transfer protein; benzoxazole; cholesteryl ester; cetp ... See more keywords
Elevated Serum Low-Density Lipoproteins-Cholesterol Levels and B1B2/B2B2 CETP Genotype Are Positively Associated with Nonalcoholic Fatty Liver Disease in Women with Gallstone Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic syndrome and related disorders"
DOI: 10.1089/met.2022.0010
Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is generated by the interaction between environmental and genetic factors, and the presence of metabolic alterations. Since Taq1B cholesteryl ester transfer protein (CETP) polymorphism is associated with abnormal serum… read more here.
Keywords: disease; serum; cetp; genotype ... See more keywords
Can we revive CETP-inhibitors for the prevention of cardiovascular disease?
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in lipidology"
DOI: 10.1097/mol.0000000000000854
Abstract: PURPOSE OF REVIEW To review recent developments in the field of cholesteryl ester transfer protein (CETP) inhibition from clinical trials and genomic analyses which have the potential to impact future clinical programs. RECENT FINDINGS CETP… read more here.
Keywords: prevention cardiovascular; cardiovascular disease; cetp; cetp inhibitors ... See more keywords
The two faces of cholesteryl ester transfer protein inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Current opinion in lipidology"
DOI: 10.1097/mol.0000000000001017
Abstract: PURPOSE OF REVIEW The causal role of LDL in atherosclerotic cardiovascular disease (ASCVD) is well established, but the contribution of HDL has proven more complex. CETP inhibitors were originally developed to increase HDL-cholesterol (HDL-C), but… read more here.
Keywords: cholesteryl ester; transfer protein; two faces; faces cholesteryl ... See more keywords