Cu-Catalyzed Regio- and Stereodivergent Chemoselective sp/sp 1,3- and 1,4-Diborylations of CF3-Containing 1,3-Enynes
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DOI: 10.1016/j.chempr.2020.06.034
Abstract: Summary CF3-containing multi-borylated compounds are intriguing molecules that can serve as building blocks and readily transform into various significant molecules. Here, a series of Cu-catalyzed assembly of 1,3- and 1,4-diborylated compounds bearing CF3 group starting… read more here.
Keywords: catalyzed regio; cf3 containing; regio stereodivergent; cf3 group ... See more keywords
Divergent pathways for reactions of CF3-containing Isobenzofuran-1-ones and amines
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DOI: 10.1016/j.jfluchem.2018.11.012
Abstract: Abstract Unprecedented isobenzofuran-1-ones (phthalides) with CF3 and ethoxy groups both at the 3-position were readily synthesized from the corresponding aromatic 1,2-diesters and reacted with a variety of primary amines to find out convenient conversion to… read more here.
Keywords: isobenzofuran ones; divergent pathways; pathways reactions; isobenzofuran ... See more keywords
Ruthenium-catalyzed dimerization of CF3-containing functional allenes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.121998
Abstract: Abstract An efficient method for the regioselective preparation of 1,3-dimethylenecyclobutanes based on Ru-catalyzed dimerization of readily available CF3-containing functionalized allenes including α-amino acid derivatives have been developed. The reactions smoothly proceed in toluene at 100… read more here.
Keywords: catalyzed dimerization; ruthenium catalyzed; cf3 containing;
Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition.
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DOI: 10.1021/acs.orglett.1c03603
Abstract: We present herein a visible-light-induced [3 + 2] cycloaddition of a hypervalent iodine(III) reagent with α-ketoacids for the construction of 5-CF3-1,3,4-oxadiazoles that are of importance in medicinal chemistry. The reaction proceeds smoothly without a photocatalyst,… read more here.
Keywords: cycloaddition; building block; containing building; cf3 ... See more keywords
Copper-Catalyzed Multicomponent Reactions of Intramolecular and Intermolecular Thiotrifluoromethylation of Alkenes: Access to CF3-Containing 2-Iminothiazolidines and Isothioureas.
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DOI: 10.1021/acs.orglett.2c02854
Abstract: A copper-catalyzed multicomponent reaction of secondary amines bearing allyl substitution, isothiocyanates, and Togni reagent II has been developed under Cs2CO3 in DCE at 75 °C. An intermolecular multicomponent reaction of thioureas, activated and unactivated alkenes,… read more here.
Keywords: multicomponent reactions; cf3 containing; reactions intramolecular; catalyzed multicomponent ... See more keywords
Stereoselective Preparation of CF3-Containing Cyclopropanes.
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DOI: 10.1021/acs.orglett.2c03714
Abstract: A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl… read more here.
Keywords: stereoselective preparation; cf3 containing; containing cyclopropanes; preparation ... See more keywords