Controllable Defluorinative Cyclization for Divergent Synthesis of Pyrrolo[2,3-d]pyrimidines and Fluorinated Pyrimidines from β-CF3-1,3-Enynes and Amidine Hydrochlorides.
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DOI: 10.1021/acs.orglett.5c02345
Abstract: This study successfully developed a novel controllable defluorinative cyclization strategy for β-CF3-1,3-enynes, achieving the divergent synthesis of pyrrolo[2,3-d]pyrimidines and fluorinated pyrimidines. The reaction between β-CF3-1,3-enynes and amidine hydrochlorides at a 1:2 molar ratio triggered selective… read more here.
Keywords: pyrrolo; divergent synthesis; defluorinative cyclization; cf3 enynes ... See more keywords