667. Real-world Experience of Cefiderocol with Pseudomonas aeruginosa in the PROVE (Retrospective Cefiderocol Chart Review) Study
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac492.719
Abstract: Gram-negative (GN) bacterial resistance is an urgent global health problem. Cefiderocol (CFDC) is active against many resistant GN pathogens, including Pseudomonas aeruginosa (PA). PROVE is an ongoing international, retrospective study assessment of CFDC use for… read more here.
Keywords: aeruginosa prove; pseudomonas aeruginosa; cfdc; shionogi ... See more keywords
Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli
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DOI: 10.1128/spectrum.01093-22
Abstract: CFDC was the first FDA-approved siderophore cephalosporin antibiotic in 2019 and is known for its Trojan horse tactics and broad antimicrobial activity against Gram-negative bacteria. However, its antibacterial mechanism is not fully understood, and whether… read more here.
Keywords: cfdc; iron; antibacterial mechanism; mechanism cefiderocol ... See more keywords
Resistance to Cefiderocol Involved Expression of PER-1 β-Lactamase and Downregulation of Iron Transporter System in Carbapenem-Resistant Acinetobacter baumannii
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DOI: 10.2147/idr.s392241
Abstract: Background Cefiderocol (CFDC) is a promising antimicrobial agent against multidrug resistant Gram-negative bacteria. However, CFDC resistance has emerged in carbapenem-resistant Acinetobacter baumannii (CR-AB) but the underlying mechanisms remain unclear. Methods Whole-genome sequencing and transcriptome sequencing… read more here.
Keywords: non susceptible; cfdc non; cfdc; susceptible isolates ... See more keywords
Chloroform Fraction of Drymaria Cordata Linn (CFDC) Suppresses Estradiol Benzoate-induced Endometrial Hyperplasia.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230209144428
Abstract: BACKGROUND The diagnosis of uterine dysfunction (endometrial hyperplasia) is on the rise. The available treatment is quite expensive and associated with some side effects. The therapeutic potential of natural products is now being explored, as… read more here.
Keywords: cfdc; drymaria cordata; chloroform fraction; endometrial hyperplasia ... See more keywords
The Iron Content of Human Serum Albumin Modulates the Susceptibility of Acinetobacter baumannii to Cefiderocol
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DOI: 10.3390/biomedicines11020639
Abstract: Mortality rates of patients infected with Acinetobacter baumannii treated with cefiderocol (CFDC) were not as favorable as the best available treatment for pulmonary and bloodstream infections. Previous studies showed that the presence of human serum… read more here.
Keywords: cfdc; iron; expression; hsa ... See more keywords
Cefiderocol against Multi-Drug and Extensively Drug-Resistant Escherichia coli: An In Vitro Study in Poland
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DOI: 10.3390/pathogens11121508
Abstract: Cefiderocol (CFDC) is a novel, broad-spectrum siderophore cephalosporin with potential activity against multi-drug (MDR) and extensively drug-resistant (XDR) Enterobacterales, including carbapenem-resistant strains. We assessed the in vitro susceptibility to CFDC of MDR, and XDR E.… read more here.
Keywords: multi drug; cfdc; extensively drug; drug resistant ... See more keywords