Testing for EGFR Variants in Pleural and Pericardial Effusion Cell-free DNA in Patients With Non-Small Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.6109
Abstract: Importance Molecular testing in non-small cell lung cancer (NSCLC) is commonly limited by inadequate tumor sample. Plasma cell-free DNA (cfDNA) genotyping as a complementary test is specific but only moderately sensitive. Genotyping of cfDNA in… read more here.
Keywords: cell; cfdna; cohort; pleural pericardial ... See more keywords
Detection and Characterization of RB1 Mosaicism in Patients With Retinoblastoma Receiving cfDNA Test
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2025.1079
Abstract: Key Points Question Can a cell-free DNA (cfDNA) assay, when paired with buffy coat genomic DNA testing, detect RB1 mosaicism, and what are the implications for cfDNA testing outcomes? Findings In 136 participants with retinoblastoma… read more here.
Keywords: mosaicism; cfdna; characterization rb1; rb1 mosaicism ... See more keywords
Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13041
Abstract: Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis. The utilization of cfDNA fragmentomics for… read more here.
Keywords: end; cfdna; size; end motifs ... See more keywords
Pathogenesis Activated “In Situ Disassembly‐Reassembly” Pattern Dual‐Scavenges Cell‐Free DNA/ROS for Hemorrhagic Stroke Management
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202424358
Abstract: Intracerebral hemorrhage (ICH) causes uncontrolled neuroinflammation/oxidative stress to aggravate secondary brain injury (SBI) for high mortality and disability but lacks effective pharmacotherapy in clinical practices. This represents an imperative need to discover potential targets and… read more here.
Keywords: free dna; cell free; disassembly reassembly; cfdna ... See more keywords
A Biomimetic Sweeping Microrobot for Active Therapy of Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202402579
Abstract: Overproduction of pathogenic cell‐free DNA (cfDNA) and reactive oxygen species (ROS) plays crucial roles in the onset and perpetuation of ulcerative colitis (UC). Inspired by sweeping robots, a magnesium@polylactic acid‐glycolic acid copolymer@polyethylenimine (Mg@PLGA@PEI) microswimmer capable… read more here.
Keywords: active therapy; plga pei; cfdna; ulcerative colitis ... See more keywords
Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24751
Abstract: Global hypomethylation has been linked to disease progression in several cancers, but has not been reported for Diffuse Large B Cell Lymphoma (DLBCL). This study aimed to assess global methylation in DLBCL and describe its… read more here.
Keywords: methylation; global hypomethylation; cfdna; large cell ... See more keywords
Plasma cell‐free DNA quantification is highly correlated to tumor burden in children with neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1586
Abstract: To evaluate plasma cell‐free DNA (cfDNA) as a promising biomarker for neuroblastoma (NB) tumor burden. Seventy‐nine eligible patients with newly diagnosed NB were recruited from Beijing Children's Hospital between April 2016 and April 2017. Additionally,… read more here.
Keywords: cfdna; plasma; dna; tumor burden ... See more keywords
Differences in the genomic profiles of cell‐free DNA between plasma, sputum, urine, and tumor tissue in advanced NSCLC
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1935
Abstract: Liquid biopsy has provided an efficient way for detection of gene alterations in advanced non‐small‐cell lung cancer (NSCLC). However, the correlation between systematic determination of somatic genomic alterations in liquid biopsy and tumor biopsy still… read more here.
Keywords: tumor tissue; plasma; sputum; liquid biopsy ... See more keywords
Diagnostic and prognostic role of cell‐free DNA testing for colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30565
Abstract: Circulating cell‐free DNA (cfDNA) was found in increased amounts in cancer patients and tumor‐associated molecular alteration can be detected in cancer patient's samples. For this reason, the cfDNA analysis is actually considered as a new… read more here.
Keywords: dna; cell free; crc patients; cfdna ... See more keywords
Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma-based collection of 77 patients with locally advanced unresectable esophageal cancer.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of cancer"
DOI: 10.1002/ijc.70011
Abstract: Locally advanced esophageal carcinoma remains of poor prognosis correlated with tumor stage. Albeit liquid biopsy approach offers promising results to monitor high-risk patients in various solid tumors, the lack of specific mutation in esophageal tumor,… read more here.
Keywords: unresectable esophageal; cfdna; locally advanced; tumor ... See more keywords
Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Cancer"
DOI: 10.1002/ijc.70121
Abstract: Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged… read more here.
Keywords: cancer; free dna; cfdna; early cancer ... See more keywords