Testing for EGFR Variants in Pleural and Pericardial Effusion Cell-free DNA in Patients With Non-Small Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.6109
Abstract: Importance Molecular testing in non-small cell lung cancer (NSCLC) is commonly limited by inadequate tumor sample. Plasma cell-free DNA (cfDNA) genotyping as a complementary test is specific but only moderately sensitive. Genotyping of cfDNA in… read more here.
Keywords: cell; cfdna; cohort; pleural pericardial ... See more keywords
Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13041
Abstract: Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis. The utilization of cfDNA fragmentomics for… read more here.
Keywords: end; cfdna; size; end motifs ... See more keywords
Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24751
Abstract: Global hypomethylation has been linked to disease progression in several cancers, but has not been reported for Diffuse Large B Cell Lymphoma (DLBCL). This study aimed to assess global methylation in DLBCL and describe its… read more here.
Keywords: methylation; global hypomethylation; cfdna; large cell ... See more keywords
Plasma cell‐free DNA quantification is highly correlated to tumor burden in children with neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1586
Abstract: To evaluate plasma cell‐free DNA (cfDNA) as a promising biomarker for neuroblastoma (NB) tumor burden. Seventy‐nine eligible patients with newly diagnosed NB were recruited from Beijing Children's Hospital between April 2016 and April 2017. Additionally,… read more here.
Keywords: cfdna; plasma; dna; tumor burden ... See more keywords
Differences in the genomic profiles of cell‐free DNA between plasma, sputum, urine, and tumor tissue in advanced NSCLC
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1935
Abstract: Liquid biopsy has provided an efficient way for detection of gene alterations in advanced non‐small‐cell lung cancer (NSCLC). However, the correlation between systematic determination of somatic genomic alterations in liquid biopsy and tumor biopsy still… read more here.
Keywords: tumor tissue; plasma; sputum; liquid biopsy ... See more keywords
Diagnostic and prognostic role of cell‐free DNA testing for colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30565
Abstract: Circulating cell‐free DNA (cfDNA) was found in increased amounts in cancer patients and tumor‐associated molecular alteration can be detected in cancer patient's samples. For this reason, the cfDNA analysis is actually considered as a new… read more here.
Keywords: dna; cell free; crc patients; cfdna ... See more keywords
Targeted deep sequencing revealed variants in cell-free DNA of hormone receptor-positive metastatic breast cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03189-z
Abstract: Cell-free DNA (cfDNA) is described to mirror intratumoral heterogeneity and gives insight about clonal evolution for improved therapeutic decisions. We sequenced cfDNA of a hormone receptor-positive, HER2-negative metastatic breast cancer (MBC) cohort with a high… read more here.
Keywords: receptor positive; cfdna; hormone receptor; dna ... See more keywords
Extracellular DNA levels and cytokine profiles in preterm birth: a cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-022-06456-w
Abstract: The content of eight different cytokines, cell-free DNA (cfDNA) and cell-free fetal DNA (cffDNA) in women’s plasma during preterm birth (PB) was studied. The purpose of this study was to identify the relationships between the… read more here.
Keywords: dna; cfdna; cffdna; preterm birth ... See more keywords
Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.03.028
Abstract: Excessive cell-free DNA (cfDNA) released by damaged or apoptotic cells can cause inflammation, impacting the progression of rheumatoid arthritis (RA). cfDNA scavengers, such as cationic nanoparticles (NPs), have been demonstrated as an efficient strategy for… read more here.
Keywords: cfdna; cell free; dimethylamino group; free dna ... See more keywords
Identification of Somatic Mutations in Thirty-year-old Serum Cell-free DNA From Patients With Breast Cancer: A Feasibility Study.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical breast cancer"
DOI: 10.1016/j.clbc.2020.04.005
Abstract: INTRODUCTION The aim of this study was to assess the feasibility of cell-free DNA (cfDNA) extraction and circulating tumor DNA sequencing in 30-year-old serum samples. MATERIALS AND METHODS We evaluated serum samples from 52 patients… read more here.
Keywords: study; serum; breast cancer; cfdna ... See more keywords
Cell-free DNA characteristics and chimerism analysis in patients after allogeneic cell transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2017.11.015
Abstract: Cell-free DNA (cfDNA) isolated from plasma or serum has received increasing interest for diagnostic applications in pregnancy, solid tumors and solid organ transplantation. The reported clinical usefulness of cfDNA obtained from plasma or serum in… read more here.
Keywords: dna; cfdna; transplantation; chimerism analysis ... See more keywords