1339. Utility of Next Generation Sequencing Cell Free DNA Testing in Pediatric Patients for Diagnosis and Excluding Infection
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac492.1168
Abstract: Next-generation sequencing of microbial cell-free DNA (NGS cfDNA) testing has the potential to quickly diagnose multiple pathogen types. Negative predictive value of NGS cfDNA is not well characterized, but this test has been described as… read more here.
Keywords: oncology; cfdna testing; ngs cfdna; diagnosis ... See more keywords
Screening for Common Fetal Trisomies in Twin Pregnancies: First-Trimester Combined, Cell-Free DNA, or Both?
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DOI: 10.1159/000494055
Abstract: Objective: To examine the distribution of risks for fetal trisomies after first-trimester combined screening in twins and to investigate different strategies for clinical implementation of cell-free DNA (cfDNA) testing. Methods: We retrospectively analyzed all twin… read more here.
Keywords: trimester combined; combined screening; cfdna testing; fetal trisomies ... See more keywords
Does a High-Risk (>1/50) Result for First-Trimester Combined Screening Always Entail Invasive Testing? Which Patients from This Group Might Benefit from cfDNA Testing?
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DOI: 10.3390/biomedicines10102579
Abstract: Currently, cell-free DNA (cfDNA) is offered as part of a contingent screening for patients with a first-trimester combined test (FCT) risk between 1/50 and 1/250. However, most aneuploidies are within the group of patients with… read more here.
Keywords: cfdna testing; high risk; first trimester; trimester combined ... See more keywords
Clinical, Cytogenetic and Molecular Cytogenetic Outcomes of Cell-Free DNA Testing for Rare Chromosomal Anomalies
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DOI: 10.3390/genes13122389
Abstract: The scope of cell-free DNA (cfDNA) testing was expanded to the genome, which allowed screening for rare chromosome anomalies (RCAs). Since the efficiency of the test for RCAs remains below the common aneuploidies, there is… read more here.
Keywords: cfdna testing; molecular cytogenetic; cell free; cytogenetic molecular ... See more keywords