Genetic sharing with coronary artery disease identifies potential novel loci for bone mineral density.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.06.016
Abstract: Bone mineral density (BMD) is a complex trait with high missing heritability. Numerous evidences have shown that BMD variation has a relationship with coronary artery disease (CAD). This relationship may come from a common genetic… read more here.
Keywords: bone mineral; bmd; coronary artery; mineral density ... See more keywords
Novel Common Variants Associated with Obesity and Type 2 Diabetes Detected Using a cFDR Method
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16722-6
Abstract: Genome-wide association studies (GWASs) have been performed extensively in diverse populations to identify single nucleotide polymorphisms (SNPs) associated with complex diseases or traits. However, to date, the SNPs identified fail to explain a large proportion… read more here.
Keywords: common variants; type diabetes; novel common; obesity ... See more keywords
Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009853
Abstract: Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with complex traits. However, a stringent significance threshold is required to identify robust genetic associations. Leveraging relevant auxiliary covariates has the potential… read more here.
Keywords: auxiliary data; flexible cfdr; boost gwas; gwas discovery ... See more keywords