A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH‐related proteins 1–5 in human plasma
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DOI: 10.1002/pmic.201600237
Abstract: Age‐related macular degeneration (AMD) is a leading cause of visual loss among older adults. Two variants in the complement factor H (CFH) gene, Y402H and I62V, are strongly associated with risk of AMD. CFH is… read more here.
Keywords: cfh variants; factor cfh; cfh; complement factor ... See more keywords
Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2020 at "International Ophthalmology"
DOI: 10.1007/s10792-020-01460-y
Abstract: To investigate whether plasma high sensitivity C-reactive protein (hs-CRP) level is associated with exudative age-related macular degeneration (AMD) as well as variants of ARMS2 A69S and CFH I62V in patients with exudative AMD. A case-control… read more here.
Keywords: crp levels; age related; patients exudative; crp ... See more keywords
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.058
Abstract: BACKGROUND Increased endothelial permeability is central to shock and organ dysfunction in sepsis but therapeutics targeted to known mediators of increased endothelial permeability have been unsuccessful in patient studies. We previously reported that cell-free hemoglobin… read more here.
Keywords: ascorbate; endothelial permeability; cell free; permeability ... See more keywords
Effects of temperature and polyols on the ciprofloxacin hydrochloride-mediated micellization of sodium dodecyl sulfate
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DOI: 10.1039/d0ra00213e
Abstract: Herein, a conductivity method was engaged to explore the effects of a fluoroquinolone drug, namely ciprofloxacin hydrochloride (CFH)/CFH + polyols (organic compounds with multiple hydroxyl groups (glucose and fructose)), on the aggregation phenomenon of sodium… read more here.
Keywords: ciprofloxacin hydrochloride; micellization; sodium dodecyl; sds sds ... See more keywords
Pathogenic Neisseria Bind the Complement Protein CFHR5 via Outer Membrane Porins
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00377-22
Abstract: Neisseria meningitidis and Neisseria gonorrhoeae are important human pathogens that have evolved to bind the major negative regulator of the complement system, complement factor H (CFH). However, little is known about the interaction of pathogens… read more here.
Keywords: cfhr5; pathogenic neisseria; complement; neisseria bind ... See more keywords
Oxidized cell-free hemoglobin induces mitochondrial morphological changes and ROS production
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733895
Abstract: Background: During sepsis, red blood cells lyse and release cell-free hemoglobin (CFH) into the circulation causing vascular dysfunction and ROS production. The heme moiety of CFH is normally in the CFH2+ oxidative state but can… read more here.
Keywords: cell free; microscopy; production; physiology ... See more keywords
Genetic Risk Factors Are Not Associated with Wet Age-Related Macular Degeneration Treatment Response to Ranibizumab
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DOI: 10.1159/000481178
Abstract: patients who withdrew differed from the 12-month cohort in having a worse VA by an average of 12 letters (p = 0.0012). Univariate analysis suggested no association between any genotyped markers with respect to VA… read more here.
Keywords: risk; response; treatment; study ... See more keywords
The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO
Sign Up to like & getrecommendations! Published in 2022 at "Critical Care"
DOI: 10.1186/s13054-022-03894-5
Abstract: Background Increased plasma concentrations of circulating cell-free hemoglobin (CFH) are supposed to contribute to the multifactorial etiology of acute kidney injury (AKI) in critically ill patients while the CFH-scavenger haptoglobin might play a protective role.… read more here.
Keywords: cell free; cfh; haptoglobin; aki ... See more keywords
Complement factor H variants are associated with microangiopathy lesions in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4109826
Abstract: BACKGROUND Thrombotic microangiopathy (TMA) occurs in immunoglobulin A nephropathy (IgAN), and the pathogenesis is not known behind the endothelium injury. The genetic studies have indicated that complement factor H (CFH) and complement factor H-related protein… read more here.
Keywords: factor; complement factor; cfh; study ... See more keywords
CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1011580
Abstract: Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is associated with dysregulation of the alternative complement pathway. The chromosomal region including… read more here.
Keywords: prevalence; atypical hemolytic; cfh cfhr; group ... See more keywords