The emerging roles of CFIm25 (NUDT21/CPSF5) in human biology and disease
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1757
Abstract: The mammalian cleavage factor I subunit CFIm25 (NUDT21) binds to the UGUA sequences of precursor RNAs. Traditionally, CFIm25 is known to facilitate 3′ end formation of pre‐mRNAs resulting in the formation of polyadenylated transcripts. Recent… read more here.
Keywords: cfim25; cfim25 nudt21; emerging roles; utr apa ... See more keywords
Suppression of cleavage factor Im 25 promotes the proliferation of lung cancer cells through alternative polyadenylation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.087
Abstract: BACKGROUND Non-small cell lung cancer (NSCLC) is a life-threatening disease that has a poor prognosis and low survival rate. Cleavage factor Im 25 (CFIm25) is a RNA-binding protein that if down-regulated causes 3'UTR shortening and… read more here.
Keywords: cfim25; proliferation; lung cancer; cancer ... See more keywords
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.50895
Abstract: We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease,… read more here.
Keywords: cfim25; intellectual disability; partial loss; learning deficits ... See more keywords