Neuronal CFL1 upregulation in head and neck squamous cell carcinoma enhances tumor‐nerve crosstalk and promotes tumor growth
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23694
Abstract: Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer type, marked by a pronounced nerve density within the tumor microenvironment and a high rate of perineural invasion (PNI). Growing evidence suggests that the… read more here.
Keywords: neck squamous; head neck; nerve; neuronal cfl1 ... See more keywords
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2020.107275
Abstract: Long-term memory has been associated with morphological changes in the brain, which in turn tightly correlate with changes in synaptic efficacy. Such plasticity is proposed to rely on dendritic spines as a neuronal canvas on… read more here.
Keywords: cfl1; actin cytoskeleton; cytoskeleton dynamics; limk ... See more keywords
Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1)
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30115-3
Abstract: Expression of a constitutively active Rho A (V14Rho) in podocytes in vivo induces albuminuria and foot process (FP) effacement. These effects may be mediated by the Rho A effector Rho kinase (ROK); but inhibition of… read more here.
Keywords: specific kinase; cfl1; kinase; testis specific ... See more keywords
Impact on U251 glioma cell radiosensitivity and CFL1 level via inhibiting cell motility regulator ROCKII of RhoA-RockII-CFL1 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14630
Abstract: e14630 Background: In response to ionizing radiation, cofilin1 (CFL1) is essential for actin dynamics and tumor metastasis. In our previous study, CFL1 was revealed up-regulated in radioresistant astrocytomas of surgical samples and positively correlated with… read more here.
Keywords: radiosensitivity; rockii; cell; glioma cell ... See more keywords
CFL1 to promote proliferation and invasiveness and to regulate NF-κB-mediated inflammatory factors in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e16669
Abstract: e16669Background: Cofilin1 (CFL1) is an actin-binding protein that plays an essential role in cytoskeleton regulation. However, its function in hepatocellular carcinoma (HCC) is largely unknown. Th... read more here.
Keywords: hepatocellular carcinoma; cfl1 promote; cfl1; proliferation invasiveness ... See more keywords
Cofilin-1 Maintains Prosurvival Signaling in Chronic Lymphocytic Leukemia Cells
Sign Up to like & getrecommendations! Published in 2020 at "AntiCancer Research"
DOI: 10.21873/anticanres.14653
Abstract: Background/Aim: Despite numerous studies, the etiology of chronic lymphocytic leukemia (CLL) remains unknown. A hypothesis of autoantigen stimulation in leukemic clone selection might explain ‘stereotypy’ of B-cell receptors. In healthy cells, cofilin-1 (CFL1) has multiple… read more here.
Keywords: cll; cfl1; lymphocytic leukemia; leukemia cells ... See more keywords