Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101403
Abstract: The death inhibitory proteins, cFLIP and Bcl-2, canonically act at different steps to regulate receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic means to effect an increase in intracellular superoxide result… read more here.
Keywords: death; apoptosis; superoxide; cflip ... See more keywords
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47990-2
Abstract: Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-inhibitory proteins (cFLIP) assemble through death-effector domains (DEDs), directing death receptor signaling towards cell survival or apoptosis. Understanding their three-dimensional regulatory mechanism has been limited by… read more here.
Keywords: fadd procaspase; procaspase cflip; ded assembly; cflip complexes ... See more keywords
Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-75229-z
Abstract: Cisplatin-induced injury to renal proximal tubular cells stems from mitochondrial damage-induced apoptosis and inflammation. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, a potential generator of ROS and ATP, protects against cisplatin-induced nephrotoxicity by promoting… read more here.
Keywords: jnk; activation; caspase; cisplatin induced ... See more keywords
Abstract 1592: Targeting cFLIP to overcome resistance of BRAF V600E melanoma cells with the small molecule CB001
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1592
Abstract: Over 50% of metastatic melanoma harbor activating BRAF V600E mutations. Vemurafenib selectively inhibits mutant BRAF. However, resistance to vemurafenib frequently develops within a few months of initiating treatment. Vemurafenib-induced apoptosis is inhibited by overexpression of… read more here.
Keywords: vemurafenib; resistance; braf; cb001 ... See more keywords
cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-024-03141-4
Abstract: Background Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific caspase-8 functions in cell death and inflammation. This study aimed to determine… read more here.
Keywords: driven neuroinflammation; astroglia driven; glaucoma; cflip molecular ... See more keywords
Differential expression patterns of the short and long isoform of cFLIP on FasL‑mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6317
Abstract: cFLIP is a key regulator of the anti‑apoptotic mechanism and its association with FAS‑mediated apoptosis has been widely studied and well documented. However, the equipoise between its two isoforms i.e. the long isoform cFLIP(L) and… read more here.
Keywords: apoptosis; isoform cflip; cflip; expression ... See more keywords