Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells
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DOI: 10.1186/s12931-024-02889-w
Abstract: Background Cystic Fibrosis causing mutations in the gene CFTR , reduce the activity of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor lung function. A role for CFTR in the… read more here.
Keywords: cftr channel; airway; channel activity; activity ... See more keywords
Trivalent anions as probes of the CFTR channel pore.
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DOI: 10.4149/gpb_2024007
Abstract: The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel uses positively charged amino-acid side-chains to form binding sites for permeating anions. These binding sites have been investigated experimentally using a number of anionic probes. Mutations… read more here.
Keywords: cftr channel; within pore; trivalent anions; binding sites ... See more keywords