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Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c01050
Abstract: Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address the basic defects associated with CF-causing mutations,…
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Keywords:
cftr;
cftr potentiators;
tetrahydro pyrido;
activity relationship ... See more keywords
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Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01221
Abstract: There is still a high unmet need for the treatment of most patients with cystic fibrosis (CF). The identification and development of new Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators is necessary to achieve higher…
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Keywords:
characterization novel;
cftr;
novel cftr;
cftr potentiators ... See more keywords