Conformational change of the extracellular parts of the CFTR protein during channel gating
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2777-0
Abstract: Cystic fibrosis can be treated by potentiators, drugs that interact directly with the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel to increase its open probability. These substances likely target key conformational changes occurring during… read more here.
Keywords: extracellular parts; cftr protein; parts cftr; conformational changes ... See more keywords
Genetics of CFTR and male infertility.
Sign Up to like & getrecommendations! Published in 2021 at "Translational andrology and urology"
DOI: 10.21037/tau.2020.04.05
Abstract: Cystic fibrosis (CF) is a rare autosomal-recessive disorder manifested as multisystem organ dysfunction. The cystic fibrosis transmembrane conductance regulator (CFTR) protein functions as an ion transporter on the epithelium of exocrine glands, regulating secretion viscosity.… read more here.
Keywords: genetics cftr; male infertility; genetics; cftr protein ... See more keywords
The Distribution and Role of the CFTR Protein in the Intracellular Compartments
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DOI: 10.3390/membranes11110804
Abstract: Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is caused by mutations in the gene encoding CFTR with the most common phenylalanine deletion at position 508. CFTR is an… read more here.
Keywords: cftr; intracellular compartments; distribution role; role cftr ... See more keywords