Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
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DOI: 10.1016/j.ejmech.2020.112116
Abstract: Recent evidence shows that combination of correctors and potentiators, such as the drug ivacaftor (VX-770), can significantly restore the functional expression of mutated Cystic Fibrosis Transmembrane conductance Regulator (CFTR), an anion channel which is mutated… read more here.
Keywords: targeting different; cftr structures; channel; binding sites ... See more keywords