Peptide‐Based Cancer Vaccine Delivery via the STINGΔTM‐cGAMP Complex
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200905
Abstract: With the advent of bioinformatic tools in efficiently predicting neo‐antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to… read more here.
Keywords: peptide; cgamp; vaccine delivery; delivery ... See more keywords
The Chemistry of the Noncanonical Cyclic Dinucleotide 2'3'-cGAMP and Its Analogs.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2015_43
Abstract: The cyclic dinucleotides (CDNs) cyclic diguanosine monophosphate (c-diGMP) and cyclic diadenosine monophosphate (c-diAMP) with two canonical 3'→5' internucleotide linkages are ubiquitous second messenger molecules in bacteria, regulating a multitude of physiological processes. Recently the noncanonical… read more here.
Keywords: chemistry noncanonical; noncanonical cyclic; chemistry; cgamp ... See more keywords
Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.07.004
Abstract: Innate immune responses are considered to play crucial roles in the progression of Alzheimer's disease (AD). Recently, immunotherapy is emerging as an innovative and highly conceivable strategy for AD treatment. The cGAMP-STING-IRF3 signaling pathway plays… read more here.
Keywords: efficacy mechanism; alzheimer disease; cgamp; mechanism cgamp ... See more keywords
Second Messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP):Synthesis, transmission, and degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114934
Abstract: Cyclic GMP-AMP synthase (cGAS) senses foreign DNA to produce 2'3'-cyclic GMP-AMP (2'3'-cGAMP). 2'3'-cGAMP is a second messenger that binds and activates the adaptor protein STING, which triggers the innate immune response. As a STING agonist,… read more here.
Keywords: cgamp; amp cgamp; gmp amp; cyclic gmp ... See more keywords
A robust microparticle platform for a STING‐targeted adjuvant that enhances both humoral and cellular immunity during vaccination
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.11.030
Abstract: Abstract Most FDA‐approved adjuvants for infectious agents boost humoral but not cellular immunity, and have poorly‐understood mechanisms. Stimulator of interferon genes (STING, also known as MITA, MPYS, or ERIS) is an exciting adjuvant target due… read more here.
Keywords: robust microparticle; immunity; humoral cellular; cgamp ... See more keywords
Activation of STING signaling accelerates skin wound healing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.11.008
Abstract: BACKGROUND The process of repair after skin injury is precisely regulated by a variety of mediators such as cytokines and chemokines. Recent reports demonstrated that cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) activates the stimulator of… read more here.
Keywords: wound healing; skin wound; cgamp; sting signaling ... See more keywords
SLC19A1 Is an Importer of the Immunotransmitter cGAMP.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.05.006
Abstract: 2'3'-cyclic-GMP-AMP (cGAMP) is a second messenger that activates the antiviral stimulator of interferon genes (STING) pathway. We recently identified a novel role for cGAMP as a soluble, extracellular immunotransmitter that is produced and secreted by… read more here.
Keywords: slc19a1 importer; immunotransmitter; cgamp; importer immunotransmitter ... See more keywords
Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
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DOI: 10.1038/s41598-020-64348-y
Abstract: The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes… read more here.
Keywords: human cgas; cgas; small molecule; cgamp ... See more keywords
Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways
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DOI: 10.1039/c8ra04603d
Abstract: Global and quantitative analysis of the proteome help to reveal how host cells sense invading bacteria and respond to bacterial signaling molecules. Here, we performed label free quantitative proteomic analysis of RAW macrophages treated with… read more here.
Keywords: analysis; gmp; cgamp; analysis raw ... See more keywords
ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119189119
Abstract: Significance The immune system strikes a careful balance between launching a robust response to threats and avoiding overactivation. The molecule cGAMP is an immunotransmitter that activates innate immunity and signals extracellularly, where it is subject… read more here.
Keywords: extracellular cgamp; regulation extracellular; cgamp; enpp1 regulation ... See more keywords
Anti-triple-negative breast cancer metastasis efficacy and molecular mechanism of the STING agonist for innate immune pathway
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine"
DOI: 10.1080/07853890.2023.2210845
Abstract: Abstract Background With high recurrence and metastatic rates, triple-negative breast cancer (TNBC) has few therapy choices. The innate immune stimulator of interferon genes protein (STING) pathway has emerged as a critical foundation for improving anticancer… read more here.
Keywords: metastasis; breast cancer; cgamp; mechanism ... See more keywords