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   Articles with "cgamp" as a keyword



Peptide‐Based Cancer Vaccine Delivery via the STINGΔTM‐cGAMP Complex

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recommendations! Published in 2022 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202200905

Abstract: With the advent of bioinformatic tools in efficiently predicting neo‐antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to… read more here.

Keywords: peptide; cgamp; vaccine delivery; delivery ... See more keywords

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS‐STING Signaling

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202308131

Abstract: To evade immune surveillance, tumor cells express ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) on the surface of their membrane, which degrades extracellular cyclic GMP‐AMP (cGAMP), thereby inhibiting the cyclic GMP‐AMP synthase (cGAS) stimulator of interferon gene… read more here.

Keywords: cgas; tumor; cgamp; exosomal enpp1 ... See more keywords

The Chemistry of the Noncanonical Cyclic Dinucleotide 2'3'-cGAMP and Its Analogs.

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recommendations! Published in 2017 at "Handbook of experimental pharmacology"

DOI: 10.1007/164_2015_43

Abstract: The cyclic dinucleotides (CDNs) cyclic diguanosine monophosphate (c-diGMP) and cyclic diadenosine monophosphate (c-diAMP) with two canonical 3'→5' internucleotide linkages are ubiquitous second messenger molecules in bacteria, regulating a multitude of physiological processes. Recently the noncanonical… read more here.

Keywords: chemistry noncanonical; noncanonical cyclic; chemistry; cgamp ... See more keywords

Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2

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recommendations! Published in 2019 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2019.07.004

Abstract: Innate immune responses are considered to play crucial roles in the progression of Alzheimer's disease (AD). Recently, immunotherapy is emerging as an innovative and highly conceivable strategy for AD treatment. The cGAMP-STING-IRF3 signaling pathway plays… read more here.

Keywords: efficacy mechanism; alzheimer disease; cgamp; mechanism cgamp ... See more keywords

Second Messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP):Synthesis, transmission, and degradation.

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recommendations! Published in 2022 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2022.114934

Abstract: Cyclic GMP-AMP synthase (cGAS) senses foreign DNA to produce 2'3'-cyclic GMP-AMP (2'3'-cGAMP). 2'3'-cGAMP is a second messenger that binds and activates the adaptor protein STING, which triggers the innate immune response. As a STING agonist,… read more here.

Keywords: cgamp; amp cgamp; gmp amp; cyclic gmp ... See more keywords

A robust microparticle platform for a STING‐targeted adjuvant that enhances both humoral and cellular immunity during vaccination

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recommendations! Published in 2018 at "Journal of Controlled Release"

DOI: 10.1016/j.jconrel.2017.11.030

Abstract: Abstract Most FDA‐approved adjuvants for infectious agents boost humoral but not cellular immunity, and have poorly‐understood mechanisms. Stimulator of interferon genes (STING, also known as MITA, MPYS, or ERIS) is an exciting adjuvant target due… read more here.

Keywords: robust microparticle; immunity; humoral cellular; cgamp ... See more keywords

Activation of STING signaling accelerates skin wound healing.

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recommendations! Published in 2019 at "Journal of dermatological science"

DOI: 10.1016/j.jdermsci.2019.11.008

Abstract: BACKGROUND The process of repair after skin injury is precisely regulated by a variety of mediators such as cytokines and chemokines. Recent reports demonstrated that cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) activates the stimulator of… read more here.

Keywords: wound healing; skin wound; cgamp; sting signaling ... See more keywords

SLC19A1 Is an Importer of the Immunotransmitter cGAMP.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2019.05.006

Abstract: 2'3'-cyclic-GMP-AMP (cGAMP) is a second messenger that activates the antiviral stimulator of interferon genes (STING) pathway. We recently identified a novel role for cGAMP as a soluble, extracellular immunotransmitter that is produced and secreted by… read more here.

Keywords: slc19a1 importer; immunotransmitter; cgamp; importer immunotransmitter ... See more keywords

A pH-Responsive and Guanidinium-Rich Nanoadjuvant Efficiently Delivers STING Agonist for Cancer Immunotherapy.

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recommendations! Published in 2025 at "ACS nano"

DOI: 10.1021/acsnano.4c10202

Abstract: As natural agonists of the stimulator of interferon genes (STING), cyclic dinucleotides (CDNs) have been identified as promising immunotherapies that trigger a potent immune response against tumors. However, the low stability, rapid clearance, inadequate cellular… read more here.

Keywords: responsive guanidinium; cancer immunotherapy; guanidinium; cgamp ... See more keywords

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-64348-y

Abstract: The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes… read more here.

Keywords: human cgas; cgas; small molecule; cgamp ... See more keywords

Homogeneous and bioluminescent biochemical and cellular assay for monitoring cGAMP and enzymes that generate and degrade cGAMP

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-82525-1

Abstract: The cyclic GMP-AMP synthase-stimulator of the interferon gene (cGAS-STING) signaling pathway is considered an essential pattern recognition and effector pathway in the natural immune system and is mainly responsible for recognizing DNA molecules present in… read more here.

Keywords: biochemical cellular; homogeneous bioluminescent; cgas; immune system ... See more keywords